You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
SLC6A4
Sodium-dependent serotonin transporter

Protein Summary
Description
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261707
  • ENSP00000261707
  • ENSG00000108576
  • ENST00000401766
  • ENSP00000385822

Symbol
  • HTT
  • SERT
  • HTT
  • 5HTT
  • OCD1
  • SERT
  • 5-HTT
  • SERT1
  • hSERT
  • 5-HTTLPR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
1
disease
0.99
biological process
0.93
kinase
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6347.3   (req: < 5)
Gene RIFs: 1633   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6347.3   (req: >= 5)
Gene RIFs: 1633   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3589
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 70
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (70)
clozapine
Rendered image for clozapine
chlorpromazine
Rendered image for chlorpromazine
olanzapine
Rendered image for olanzapine
amitriptyline
Rendered image for amitriptyline
thioridazine
Rendered image for thioridazine
imatinib
Rendered image for imatinib
risperidone
Rendered image for risperidone
aripiprazole
Rendered image for aripiprazole
fluphenazine
Rendered image for fluphenazine
metergoline
Rendered image for metergoline
Active Ligands (3589)
CHEMBL4128926
Rendered image for CHEMBL4128926
Pipamazine
Rendered image for Pipamazine
N-Desmethyl loperamide
Rendered image for N-Desmethyl loperamide
CHEMBL3752900
Rendered image for CHEMBL3752900
GR 127935
Rendered image for GR 127935
m-chlorophenylpiperazine
Rendered image for m-chlorophenylpiperazine
NPS 2143
Rendered image for NPS 2143
CHEMBL131495
Rendered image for CHEMBL131495
5-methoxy-N,N-diallyltryptamine
Rendered image for 5-methoxy-N,N-diallyltryptamine
CHEMBL486278
Rendered image for CHEMBL486278
Protein-Protein Interactions (154)
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.962
Data Source:  STRINGDB
TPH1
Tclin
Family:  Enzyme
Novelty:  0.00098637
Score:  0.913
Data Source:  STRINGDB
HTR7
Tclin
Family:  GPCR
Novelty:  0.00169884
Score:  0.913
Data Source:  STRINGDB
COMT
Tclin
Family:  Enzyme
Novelty:  0.00025107
Score:  0.913
Data Source:  STRINGDB
HTR2A
Tclin
Family:  GPCR
Novelty:  0.00035566
Score:  0.907
Data Source:  STRINGDB
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
Score:  0.899
Data Source:  STRINGDB
SLC18A2
Tclin
Family:  Transporter
Novelty:  0.00072341
Score:  0.893
Data Source:  STRINGDB
HTR1B
Tclin
Family:  GPCR
Novelty:  0.00073663
Score:  0.873
Data Source:  STRINGDB
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
Score:  0.862
Data Source:  STRINGDB
TPH2
Tchem
Family:  Enzyme
Novelty:  0.00265377
Score:  0.855
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Neurotransmitter clearance
Reactome
Serotonin clearance from the synaptic cleft
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Neuronal System
Neurotransmitter clearance
Serotonin clearance from the synaptic cleft
Transmission across Chemical Synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (48)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
56.8
total cholesterol measurement
1
2
2
39.5
visceral adipose tissue measurement
1
1
1
33.1
QRS complex
1
1
0
115.6
28.1
QRS amplitude
1
1
0
115.6
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
56.8
total cholesterol measurement
2
39.5
visceral adipose tissue measurement
1
33.1
QRS complex
0
115.6
28.1
QRS amplitude
0
115.6
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 4
VGNC:9626
468201
Macaque
solute carrier family 6 member 4
574140
Mouse
MGI:96285
15567
Rat
RGD:3714
25553
Dog
solute carrier family 6 member 4
VGNC:46465
491184
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 4
Macaque
solute carrier family 6 member 4
Mouse
Rat
Dog
solute carrier family 6 member 4
Publication Statistics
PubMed Score 6347.30
PubMed score by year
PubTator Score 3935.00
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title