Tclin SLC6A4 Sodium-dependent serotonin transporter

Protein Summary

Description

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P31645
• Q5EE02
• SERT

Gene Name

• SLC6A4

Ensembl ID

• ENST00000261707
• ENSP00000261707
• ENSG00000108576
• ENST00000401766
• ENSP00000385822

Symbol

• HTT
• SERT
• HTT
• 5HTT
• OCD1
• SERT
• 5-HTT
• SERT1
• hSERT
• 5-HTTLPR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
molecular function	1
disease	0.99
biological process	0.93
kinase	0.87

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Sodium-dependent Serotonin Transporter

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc6 Neurotransmitter Transporter Family / Monoamine Transporter Subfamily / Sodium-dependent Serotonin Transporter

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6854.3   (req: < 5)

Gene RIFs: 1840   (req: <= 3)

Antibodies: 300   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6854.3   (req: >= 5)

Gene RIFs: 1840   (req: > 3)

Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3637

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 70