You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
SLC6A3
Sodium-dependent dopamine transporter

Protein Summary
Description
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270349
  • ENSP00000270349
  • ENSG00000142319
  • ENST00000621716
  • ENSP00000479597
  • ENSG00000276996

Symbol
  • DAT1
  • DAT
  • DAT1
  • PKDYS
  • PKDYS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
0.99
chemical
0.97
gene perturbation
0.92
biological process
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6214.65   (req: < 5)
Gene RIFs: 575   (req: <= 3)
Antibodies: 410   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6214.65   (req: >= 5)
Gene RIFs: 575   (req: > 3)
Antibodies: 410   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1842
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 49