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Tchem
SLC6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

Protein Summary
Description
Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266682
  • ENSP00000266682
  • ENSG00000072041
  • ENST00000450363
  • ENSP00000390706
  • ENST00000552192
  • ENSP00000450145

Symbol
  • B0AT2
  • NTT73
  • SBAT1
  • V7-3
  • NTT73
  • SBAT1
  • hv7-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
gene perturbation
0.93
PubMedID
0.92
transcription factor perturbation
0.91
microRNA
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
TEX2
Tbio
Novelty:  0.07679544
p_int:  0.999999332
p_ni:  6.68e-7
Score:  0.205
Data Source:  BioPlex,STRINGDB
KLHL36
Tdark
Novelty:  1.4153425
p_int:  0.999997329
p_ni:  0.000002671
Score:  0.15
Data Source:  BioPlex,STRINGDB
TLCD1
Tdark
Novelty:  0.76223034
p_int:  0.999969972
p_ni:  0.000030027
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
SFXN5
Tdark
Novelty:  0.30379915
p_int:  0.999468
p_ni:  0.000532
Score:  0.152
Data Source:  BioPlex,STRINGDB
TMTC4
Tdark
Novelty:  0.53734704
p_int:  0.995309998
p_ni:  0.004689985
p_wrong:  1.7e-8
Data Source:  BioPlex
GOLGA5
Tbio
Novelty:  0.04940885
p_int:  0.994074333
p_ni:  0.005925667
Data Source:  BioPlex
AGPAT3
Tbio
Family:  Enzyme
Novelty:  0.06139822
p_int:  0.981400256
p_ni:  0.018599744
Score:  0.212
Data Source:  BioPlex,STRINGDB
GPAT3
Tbio
Family:  Enzyme
Novelty:  0.03251979
p_int:  0.975632841
p_ni:  0.024367159
Score:  0.324
Data Source:  BioPlex,STRINGDB
CAV1
Tbio
Novelty:  0.00035244
p_int:  0.97528445
p_ni:  0.002016209
p_wrong:  0.02269934
Data Source:  BioPlex
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.972328434
p_ni:  0.027671566
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Amino acid transport across the plasma membrane (R-HSA-352230)

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Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Na+/Cl- dependent neurotransmitter transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of inorganic cations/anions and amino acids/oligopeptides
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
51.6
educational attainment
1
5
5
23.7
brain measurement
1
1
0
8.9
13.2
cortical surface area measurement
1
1
0
7.4
8.7
cortical thickness
1
1
0
6.7
5.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
51.6
educational attainment
5
23.7
brain measurement
0
8.9
13.2
cortical surface area measurement
0
7.4
8.7
cortical thickness
0
6.7
5.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 15
VGNC:8548
101058037
Mouse
MGI:2143484
103098
Rat
RGD:628664
282712
Dog
solute carrier family 6 member 15
VGNC:46458
475416
Horse
solute carrier family 6 member 15
VGNC:23255
100050913
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 15
Mouse
Rat
Dog
solute carrier family 6 member 15
Horse
solute carrier family 6 member 15
Publication Statistics
PubMed Score 40.00
PubMed score by year
PubTator Score 15.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title