Tbio SLC6A15 Sodium-dependent neutral amino acid transporter B(0)AT2

Protein Summary

Description

Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q9H2J7
• A8K592
• B7Z2P7
• E7ESJ5
• Q9H9F5

Gene Name

• SLC6A15

Ensembl ID

• ENST00000266682
• ENSP00000266682
• ENSG00000072041
• ENST00000450363
• ENSP00000390706
• ENST00000552192
• ENSP00000450145

Symbol

• B0AT2
• NTT73
• SBAT1
• V7-3
• NTT73
• SBAT1
• hv7-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
gene perturbation	0.93
PubMedID	0.92
transcription factor perturbation	0.91
microRNA	0.79

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Sodium-dependent Neutral Amino Acid Transporter B(0)at2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc6 Neurotransmitter Transporter Family / Neutral Amino Acid Transporter Subfamily / Sodium-dependent Neutral Amino Acid Transporter B(0)at2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 138   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1