You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
SLC6A1
Sodium- and chloride-dependent GABA transporter 1

Protein Summary
Description
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287766
  • ENSP00000287766
  • ENSG00000157103
  • ENST00000642201
  • ENSP00000494778
  • ENST00000642515
  • ENSP00000496348
  • ENST00000642639
  • ENSP00000494191
  • ENST00000642735
  • ENSP00000494050
  • ENST00000642767
  • ENSP00000494346
  • ENST00000642820
  • ENSP00000495900
  • ENST00000643396
  • ENSP00000494136
  • ENST00000643498
  • ENSP00000494997
  • ENST00000645029
  • ENSP00000496171
  • ENST00000645054
  • ENSP00000495751
  • ENST00000645592
  • ENSP00000496619
  • ENST00000645974
  • ENSP00000496390
  • ENST00000646022
  • ENSP00000494134
  • ENST00000646060
  • ENSP00000496302
  • ENST00000646570
  • ENSP00000496064
  • ENST00000646702
  • ENSP00000496697
  • ENST00000646924
  • ENSP00000493591
  • ENST00000647194
  • ENSP00000496238

Symbol
  • GABATR
  • GABT1
  • GAT1
  • MAE
  • GAT1
  • GABATR
  • GABATHG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
gene perturbation
0.84
biological process
0.82
microRNA
0.73
PubMedID
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 678.64   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 678.64   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 56
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1