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Tchem
SLC5A7
High affinity choline transporter 1

Protein Summary
Description
Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent. This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants. [pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264047
  • ENSP00000264047
  • ENSG00000115665
  • ENST00000409059
  • ENSP00000387346

Symbol
  • CHT1
  • CHT
  • CHT1
  • CMS20
  • HMN7A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
microRNA
0.67
gene perturbation
0.6
cell type or tissue
0.57
cellular component
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.58   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.58   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (10)
CHEMBL4217988
Rendered image for CHEMBL4217988
CHEMBL3304438
Rendered image for CHEMBL3304438
CHEMBL1872483
Rendered image for CHEMBL1872483
CHEMBL3933906
Rendered image for CHEMBL3933906
CHEMBL3899143
Rendered image for CHEMBL3899143
CHEMBL3303792
Rendered image for CHEMBL3303792
CHEMBL1340914
Rendered image for CHEMBL1340914
CHEMBL3959257
Rendered image for CHEMBL3959257
CHEMBL1887357
Rendered image for CHEMBL1887357
CHEMBL3182315
Rendered image for CHEMBL3182315
Protein-Protein Interactions (62)
KIAA1549
Tbio
Novelty:  0.01224835
p_int:  0.999582515
p_ni:  0.000417485
Data Source:  BioPlex
SLC18A3
Tchem
Family:  Transporter
Novelty:  0.00169007
Score:  0.92
Data Source:  STRINGDB
RAB38
Tbio
Family:  Enzyme
Novelty:  0.02651645
Score:  0.754
Data Source:  STRINGDB
CHAT
Tchem
Family:  Enzyme
Novelty:  0.00033026
Score:  0.748
Data Source:  STRINGDB
MN1
Tbio
Novelty:  0.0015395
Score:  0.743
Data Source:  STRINGDB
SLC44A4
Tbio
Family:  Transporter
Novelty:  0.01998777
Score:  0.733
Data Source:  STRINGDB
PLEKHG5
Tbio
Novelty:  0.01182841
Score:  0.711
Data Source:  STRINGDB
CHIT1
Tchem
Family:  Enzyme
Novelty:  0.00113383
Score:  0.71
Data Source:  STRINGDB
SLC44A1
Tbio
Family:  Transporter
Novelty:  0.01499456
Score:  0.69
Data Source:  STRINGDB
ST6GAL2
Tbio
Family:  Enzyme
Novelty:  0.02408727
Score:  0.689
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (29)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
Reactome
Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)
Disease
Disorders of transmembrane transporters
Neuronal System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 7
VGNC:7711
470492
Macaque
solute carrier family 5 member 7
714093
Mouse
MGI:1927126
63993
Rat
RGD:69270
85426
Dog
solute carrier family 5 member 7
VGNC:46450
481311
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 7
Macaque
solute carrier family 5 member 7
Mouse
Rat
Dog
solute carrier family 5 member 7
Publication Statistics
PubMed Score 228.58
PubMed score by year
PubTator Score 143.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title