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Tbio
SLC5A5
Sodium/iodide cotransporter

Protein Summary
Description
Mediates iodide uptake in the thyroid gland. This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222248
  • ENSP00000222248
  • ENSG00000105641

Symbol
  • NIS
  • NIS
  • TDH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
molecular function
0.76
chemical
0.71
PubMedID
0.59
cellular component
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 671.02   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 527   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 671.02   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 527   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
ORMDL2
Tdark
Novelty:  0.37598406
p_int:  0.999610166
p_ni:  0.000389833
p_wrong:  1e-9
Score:  0.242
Data Source:  BioPlex,STRINGDB
SFXN5
Tdark
Novelty:  0.30379915
p_int:  0.988350109
p_ni:  0.011649887
p_wrong:  4e-9
Data Source:  BioPlex
SLC19A2
Tbio
Family:  Transporter
Novelty:  0.00761796
p_int:  0.987496646
p_ni:  0.012503354
Score:  0.292
Data Source:  BioPlex,STRINGDB
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.955569858
p_ni:  0.044420463
p_wrong:  0.000009679
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.805205003
p_ni:  0.194794997
Data Source:  BioPlex
ATL3
Tbio
Novelty:  0.05295598
p_int:  0.788843506
p_ni:  0.211150166
p_wrong:  0.000006327
Score:  0.175
Data Source:  BioPlex,STRINGDB
CTU2
Tdark
Novelty:  0.00936441
p_int:  0.780552642
p_ni:  0.219447355
p_wrong:  3e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
ARL5B
Tbio
Family:  Enzyme
Novelty:  0.03703395
p_int:  0.768939878
p_ni:  0.231046242
p_wrong:  0.00001388
Score:  0.175
Data Source:  BioPlex,STRINGDB
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.753410664
p_ni:  0.246589336
Data Source:  BioPlex
TG
Tbio
Novelty:  0.00010111
Score:  0.828
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) (R-HSA-5619096)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Name
Explore in Pharos
Explore in Source
Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
Disease
Disorders of transmembrane transporters
Metabolism
Metabolism of amine-derived hormones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
3
3
78.4
reticulocyte count
1
2
2
68.4
cancer antigen 19.9 measurement
1
1
1
57.8
cancer biomarker measurement
1
1
1
14.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
78.4
reticulocyte count
2
68.4
cancer antigen 19.9 measurement
1
57.8
cancer biomarker measurement
1
14.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 5
VGNC:7781
468767
Macaque
solute carrier family 5 member 5
720060
Mouse
MGI:2149330
114479
Rat
RGD:69267
114613
Dog
solute carrier family 5 member 5
VGNC:46448
484830
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 5
Macaque
solute carrier family 5 member 5
Mouse
Rat
Dog
solute carrier family 5 member 5
Publication Statistics
PubMed Score 671.02
PubMed score by year
PubTator Score 334.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title