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Tchem
SLC5A4
Solute carrier family 5 member 4

Protein Summary
Description
Has electrogenic activity in response to glucose, and may function as a glucose sensor (PubMed:13130073, PubMed:17110502, PubMed:20421923, PubMed:22766068). Mediates influx of sodium ions into the cell but does not transport sugars (PubMed:13130073, PubMed:22766068). Also potently activated by imino sugars such as deoxynojirimycin (DNJ) (PubMed:17110502, PubMed:20421923, PubMed:22766068).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266086
  • ENSP00000266086
  • ENSG00000100191

Symbol
  • SAAT1
  • SGLT3
  • SAAT1
  • SGLT3
  • DJ90G24.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.6
cell type or tissue
0.56
pathway
0.52
cell line
0.5
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1735.42   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1735.42   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (28)
phlorizin
Rendered image for phlorizin
sergliflozin
Rendered image for sergliflozin
Sergliflozin A
Rendered image for Sergliflozin A
CHEMBL1090058
Rendered image for CHEMBL1090058
CHEMBL1770244
Rendered image for CHEMBL1770244
CHEMBL1770246
Rendered image for CHEMBL1770246
CHEMBL1770245
Rendered image for CHEMBL1770245
Protein-Protein Interactions (47)
DPP4
Tclin
Family:  Enzyme
Novelty:  0.00017047
Score:  0.891
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.872
Data Source:  STRINGDB
REG1A
Tbio
Novelty:  0.00492251
Score:  0.864
Data Source:  STRINGDB
ADCY7
Tbio
Family:  Enzyme
Novelty:  0.00984562
Score:  0.808
Data Source:  STRINGDB
SLC6A2
Tclin
Family:  Transporter
Novelty:  0.00093735
Score:  0.804
Data Source:  STRINGDB
RSC1A1
Tbio
Novelty:  0.23664927
Score:  0.801
Data Source:  STRINGDB
RPS13
Tbio
Novelty:  0.0019983
Score:  0.801
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.795
Data Source:  STRINGDB
ILVBL
Tbio
Family:  Enzyme
Novelty:  0.00297467
Score:  0.731
Data Source:  STRINGDB
SLC2A2
Tchem
Family:  Transporter
Novelty:  0.00103579
Score:  0.725
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Cellular hexose transport (R-HSA-189200)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular hexose transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Cellular hexose transport
SLC-mediated transmembrane transport
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
3.7
33.1
diastolic blood pressure
1
1
1
9.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3.7
33.1
diastolic blood pressure
1
9.5
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 4
VGNC:7805
470189
Macaque
solute carrier family 5 member 4
717137
Mouse
MGI:1927848
64452
Rat
RGD:1306923
294341
Dog
solute carrier family 5 member 4
VGNC:46447
100685907
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 4
Macaque
solute carrier family 5 member 4
Mouse
Rat
Dog
solute carrier family 5 member 4
Publication Statistics
PubMed Score 1735.42
PubMed score by year
PubTator Score 25.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title