Tdark SLC5A12 Sodium-coupled monocarboxylate transporter 2

Protein Summary

Description

Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity). Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).[supplied by OMIM, Dec 2008]

Uniprot Accession IDs

• Q1EHB4
• Q86UC7

Gene Name

• SLC5A12

Ensembl ID

• ENST00000280467
• ENSP00000280467
• ENSG00000148942
• ENST00000396005
• ENSP00000379326

Symbol

• SMCT2
• SMCT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.68
microRNA	0.67
tissue	0.63
cell type or tissue	0.57
disease perturbation	0.56

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Sodium-coupled Monocarboxylate Transporter 2

Protein / Transporter / Carbohydrate Transporter / Sodium-coupled Monocarboxylate Transporter 2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc5 Family Of Sodium-dependent Glucose Transporters / Sodium Iodide Symporter, Sodium-dependent Multivitamin Transporter And Sodium-coupled Monocarboxylate Transporters / Sodium-coupled Monocarboxylate Transporter 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.23   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 13   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.23   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0