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Tbio
SLC51B
Organic solute transporter subunit beta

Protein Summary
Description
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334287
  • ENSP00000335292
  • ENSG00000186198

Symbol
  • OSTB
  • OSTB
  • OSTBETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
biological process
0.6
tissue
0.45
cell type or tissue
0.44
chemical
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.24   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.24   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
SLC51A
Tbio
Family:  Transporter
Novelty:  0.02128282
Score:  0.991
Data Source:  STRINGDB
NR1H4
Tclin
Family:  NR
Novelty:  0.00067092
Score:  0.835
Data Source:  STRINGDB
SLC10A2
Tclin
Family:  Transporter
Novelty:  0.0036213
Score:  0.773
Data Source:  STRINGDB
ABCC3
Tbio
Family:  Transporter
Novelty:  0.00260166
Score:  0.755
Data Source:  STRINGDB
ABCB11
Tchem
Family:  Transporter
Novelty:  0.00097529
Score:  0.706
Data Source:  STRINGDB
FABP6
Tbio
Novelty:  0.00671588
Score:  0.679
Data Source:  STRINGDB
SLC10A1
Tclin
Family:  Transporter
Novelty:  0.00142951
Score:  0.678
Data Source:  STRINGDB
CYP7A1
Tchem
Family:  Enzyme
Novelty:  0.00148194
Score:  0.676
Data Source:  STRINGDB
SLC6A20
Tbio
Family:  Transporter
Novelty:  0.01435823
Score:  0.666
Data Source:  STRINGDB
SLC16A9
Tbio
Family:  Transporter
Novelty:  0.06564904
Score:  0.618
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
2
2
1
5.7
48
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
1
5.7
48
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 51 beta subunit
VGNC:7772
748001
Mouse
MGI:3582052
330962
Rat
RGD:1565748
300790
Dog
solute carrier family 51 beta subunit
VGNC:46441
610770
Horse
solute carrier family 51 beta subunit
VGNC:23241
100053532
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 51 beta subunit
Mouse
Rat
Dog
solute carrier family 51 beta subunit
Horse
solute carrier family 51 beta subunit
Publication Statistics
PubMed Score 34.24
PubMed score by year
PubTator Score 16.19
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title