Tbio SLC4A7 Sodium bicarbonate cotransporter 3

Protein Summary

Description

Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q9Y6M7
• A6NIA8
• B2CI53
• B5M449
• B5M451
• B5M452
• B5M453
• B6DY52
• B6DY53
• C9JST9
• D3K174
• D3K175
• O60350
• Q6AHZ9
• Q9HC88
• Q9UIB9

Gene Name

• SLC4A7

Ensembl ID

• ENST00000295736
• ENSP00000295736
• ENSG00000033867
• ENST00000428386
• ENSP00000416368
• ENST00000437179
• ENSP00000394252
• ENST00000437266
• ENSP00000409418
• ENST00000438530
• ENSP00000407304
• ENST00000440156
• ENSP00000414797
• ENST00000446700
• ENSP00000406605
• ENST00000454389
• ENSP00000390394
• ENST00000455077
• ENSP00000407382
• ENST00000457377
• ENSP00000408323

Symbol

• BT
• NBC2
• NBC2B
• NBC3
• NBCn1
• SBC2
• SLC4A6
• NBC2
• NBC3
• SBC2
• NBCN1
• SLC4A6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
drug perturbation	0.87
molecular function	0.81
microRNA	0.78
gene perturbation	0.75

Protein Classes

PANTHER Classes

Protein / ... / Cation Transporter / Sodium Bicarbonate Cotransporter 3

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc4 Family Of Bicarbonate Transporters / Sodium-dependent Hco3- Transporters / Sodium Bicarbonate Cotransporter 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.15   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.15   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0