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Tbio
SLC4A7
Sodium bicarbonate cotransporter 3

Protein Summary
Description
Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295736
  • ENSP00000295736
  • ENSG00000033867
  • ENST00000428386
  • ENSP00000416368
  • ENST00000437179
  • ENSP00000394252
  • ENST00000437266
  • ENSP00000409418
  • ENST00000438530
  • ENSP00000407304
  • ENST00000440156
  • ENSP00000414797
  • ENST00000446700
  • ENSP00000406605
  • ENST00000454389
  • ENSP00000390394
  • ENST00000455077
  • ENSP00000407382
  • ENST00000457377
  • ENSP00000408323

Symbol
  • BT
  • NBC2
  • NBC2B
  • NBC3
  • NBCn1
  • SBC2
  • SLC4A6
  • NBC2
  • NBC3
  • SBC2
  • NBCN1
  • SLC4A6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
drug perturbation
0.87
molecular function
0.81
microRNA
0.78
gene perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.15   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.15   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0