You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC4A2
Anion exchange protein 2

Protein Summary
Description
Plasma membrane anion exchange protein of wide distribution. This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary biliary cirrhosis (PBC) in human patients, while differential expression of this gene may be associated with malignant hepatocellular carcinoma, colon and gastric cancers. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392826
  • ENSP00000376571
  • ENSG00000164889
  • ENST00000413384
  • ENSP00000405600
  • ENST00000461735
  • ENSP00000419164
  • ENST00000485713
  • ENSP00000419412

Symbol
  • AE2
  • EPB3L1
  • HKB3
  • MPB3L
  • AE2
  • HKB3
  • BND3L
  • NBND3
  • EPB3L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
disease perturbation
0.9
transcription factor
0.86
transcription factor binding site profile
0.73
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.23   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.23   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.999775817
p_ni:  0.000224183
Data Source:  BioPlex
SRARP
Tbio
Novelty:  0.07838438
p_int:  0.999562441
p_ni:  0.000437558
Score:  0.416
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.995832231
p_ni:  0.004167769
Data Source:  BioPlex
PTGIR
Tclin
Family:  GPCR
Novelty:  0.0091906
p_int:  0.99072329
p_ni:  0.00927671
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.989997709
p_ni:  0.010002291
Score:  0.226
Data Source:  BioPlex,STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.978515976
p_ni:  0.021484024
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.971387608
p_ni:  0.028612392
Data Source:  BioPlex
LGALS9C
Tdark
Novelty:  0.29969898
p_int:  0.970098808
p_ni:  0.029901192
Score:  0.282
Data Source:  BioPlex,STRINGDB
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.959969432
p_ni:  0.040030568
Data Source:  BioPlex
KDELR3
Tbio
Novelty:  0.33264767
p_int:  0.933188239
p_ni:  0.066811761
Score:  0.181
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Bicarbonate transporters (R-HSA-425381)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bicarbonate transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Bicarbonate transporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
4
4
0
1.7
95.8
electrocardiography
2
2
30
11.9
95
appendicular lean mass
3
5
5
93.9
diastolic blood pressure
3
2
3
90.6
5
1
3
1.1
89.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
0
1.7
95.8
electrocardiography
30
11.9
95
appendicular lean mass
5
93.9
diastolic blood pressure
3
90.6
3
1.1
89.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 2
VGNC:8762
463890
Mouse
MGI:109351
20535
Rat
RGD:3711
24780
Dog
solute carrier family 4 member 2
VGNC:46432
475538
Horse
solute carrier family 4 member 2
VGNC:23233
791243
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 2
Mouse
Rat
Dog
solute carrier family 4 member 2
Horse
solute carrier family 4 member 2
Publication Statistics
PubMed Score 41.23
PubMed score by year
PubTator Score 105.38
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title