Tchem SLC47A1 Multidrug and toxin extrusion protein 1

Protein Summary

Description

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96FL8
• Q53HF5
• Q6PD77
• Q86VL4
• Q9NVA3
• MATE-1

Gene Name

• SLC47A1

Ensembl ID

• ENST00000270570
• ENSP00000270570
• ENSG00000142494
• ENST00000395585
• ENSP00000378951

Symbol

• MATE1
• MATE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.77
microRNA	0.77
molecular function	0.67
histone modification site profile	0.66
PubMedID	0.63

Protein Classes

PANTHER Classes

Protein / Transporter / Multidrug And Toxin Extrusion Protein 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc47 Family Of Multidrug And Toxin Extrusion Transporters / Multidrug And Toxin Extrusion Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.4   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.4   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11