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Tbio
SLC45A2
Membrane-associated transporter protein

Protein Summary
Description
Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity). This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296589
  • ENSP00000296589
  • ENSG00000164175
  • ENST00000382102
  • ENSP00000371534

Symbol
  • AIM1
  • MATP
  • 1A1
  • AIM1
  • MATP
  • OCA4
  • SHEP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.99
trait
0.86
cell type or tissue
0.76
phenotype
0.63
biological term
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.28   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.28   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
SQOR
Tchem
Family:  Enzyme
Novelty:  0.00291617
p_int:  0.999999725
p_ni:  2.75e-7
Score:  0.209
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.997993701
p_ni:  0.002006299
Data Source:  BioPlex
ATG9A
Tbio
Novelty:  0.01995033
p_int:  0.980768979
p_ni:  0.019230988
p_wrong:  3.3e-8
Score:  0.359
Data Source:  BioPlex,STRINGDB
CYHR1
Tdark
Novelty:  0.04771996
p_int:  0.939471046
p_ni:  0.060049585
p_wrong:  0.000479369
Score:  0.19
Data Source:  BioPlex,STRINGDB
MINDY1
Tbio
Novelty:  0.31540765
p_int:  0.937397099
p_ni:  0.026669373
p_wrong:  0.035933528
Score:  0.189
Data Source:  BioPlex,STRINGDB
PCNX3
Tdark
Novelty:  0.76597717
p_int:  0.934453705
p_ni:  0.065546294
p_wrong:  1e-9
Score:  0.335
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.840055117
p_ni:  0.159944883
Score:  0.166
Data Source:  BioPlex,STRINGDB
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.804761558
p_ni:  0.086922214
p_wrong:  0.108316228
Score:  0.219
Data Source:  BioPlex,STRINGDB
GTF2E1
Tbio
Novelty:  0.39883299
p_int:  0.798502479
p_ni:  0.200496194
p_wrong:  0.001001327
Score:  0.297
Data Source:  BioPlex,STRINGDB
AMFR
Tbio
Family:  Enzyme
Novelty:  0.00533547
p_int:  0.777873327
p_ni:  0.222126673
Score:  0.593
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Melanin biosynthesis (R-HSA-5662702)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Melanin biosynthesis
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Melanin biosynthesis
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
4
5
2
3.3
99.3
suntan
2
2
2
95.7
3
2
1
1.6
92
skin pigmentation measurement
3
3
4
90.8
2
2
0
1.8
89.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
3.3
99.3
suntan
2
95.7
1
1.6
92
skin pigmentation measurement
4
90.8
0
1.8
89.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 45 member 2
VGNC:8649
471584
Mouse
MGI:2153040
22293
Rat
RGD:1306690
310152
Dog
solute carrier family 45 member 2
VGNC:46423
489236
Horse
solute carrier family 45 member 2
VGNC:23224
100068242
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 45 member 2
Mouse
Rat
Dog
solute carrier family 45 member 2
Horse
solute carrier family 45 member 2
Publication Statistics
PubMed Score 340.28
PubMed score by year
PubTator Score 144.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title