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Tbio
SLC43A2
Large neutral amino acids transporter small subunit 4

Protein Summary
Description
Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids. This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of amino acids across the placental membrane to the fetus. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301335
  • ENSP00000301335
  • ENSG00000167703
  • ENST00000382147
  • ENSP00000371582
  • ENSG00000278550
  • ENST00000412517
  • ENSP00000408284
  • ENST00000571650
  • ENSP00000461382
  • ENST00000612931
  • ENSP00000483848
  • ENST00000613070
  • ENSP00000484291
  • ENST00000634102
  • ENSP00000488355

Symbol
  • LAT4
  • LAT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
histone modification site profile
0.78
transcription factor
0.77
kinase perturbation
0.71
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.9   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.9   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.966701795
p_ni:  7.45e-7
p_wrong:  0.03329746
Score:  0.189
Data Source:  BioPlex,STRINGDB
SLC7A6
Tbio
Family:  Transporter
Novelty:  0.02732334
Score:  0.789
Data Source:  STRINGDB
CDADC1
Tbio
Family:  Enzyme
Novelty:  0.43344342
Score:  0.696
Data Source:  STRINGDB
SLC7A8
Tbio
Family:  Transporter
Novelty:  0.03433454
Score:  0.678
Data Source:  STRINGDB
DCTD
Tbio
Family:  Enzyme
Novelty:  0.02275597
Score:  0.648
Data Source:  STRINGDB
SLC3A2
Tbio
Family:  Transporter
Novelty:  0.0021506
Score:  0.62
Data Source:  STRINGDB
SLC7A5
Tchem
Family:  Transporter
Novelty:  0.00365806
Score:  0.612
Data Source:  STRINGDB
SLC38A7
Tdark
Family:  Transporter
Novelty:  0.24353276
Score:  0.609
Data Source:  STRINGDB
SLC38A2
Tbio
Family:  Transporter
Novelty:  0.00808235
Score:  0.606
Data Source:  STRINGDB
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.605
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (46)
Items per page:
1 – 5 of 46
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
4
4
6
98.1
serum albumin measurement
4
4
6
98.1
calcium measurement
3
3
4
94.1
calcium measurement
3
3
4
94.1
sex hormone-binding globulin measurement
7
1
6
9.2
85.8
Items per page:
1 – 5 of 46
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
6
98.1
serum albumin measurement
6
98.1
calcium measurement
4
94.1
calcium measurement
4
94.1
sex hormone-binding globulin measurement
6
9.2
85.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 43 member 2
VGNC:12672
747224
Macaque
solute carrier family 43 member 2
701666
Mouse
MGI:2442746
215113
Rat
RGD:1305819
287532
Dog
solute carrier family 43 member 2
VGNC:46416
491193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 43 member 2
Macaque
solute carrier family 43 member 2
Mouse
Rat
Dog
solute carrier family 43 member 2
Publication Statistics
PubMed Score 38.90
PubMed score by year
PubTator Score 15.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title