You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC43A1
Large neutral amino acids transporter small subunit 3

Protein Summary
Description
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278426
  • ENSP00000278426
  • ENSG00000149150
  • ENST00000528450
  • ENSP00000435673

Symbol
  • LAT3
  • PB39
  • POV1
  • LAT3
  • PB39
  • POV1
  • R00504
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.89
PubMedID
0.73
transcription factor binding site profile
0.73
transcription factor
0.63
histone modification site profile
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.74   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.74   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.999998836
p_ni:  8.29e-7
p_wrong:  3.35e-7
Data Source:  BioPlex
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
p_int:  0.999264089
p_ni:  0.000003878
p_wrong:  0.000732033
Score:  0.189
Data Source:  BioPlex,STRINGDB
SLC17A2
Tdark
Family:  Transporter
Novelty:  0.23941275
p_int:  0.847982483
p_ni:  0.000013123
p_wrong:  0.152004394
Score:  0.175
Data Source:  BioPlex,STRINGDB
SLC7A8
Tbio
Family:  Transporter
Novelty:  0.03433454
Score:  0.8
Data Source:  STRINGDB
SLC7A5
Tchem
Family:  Transporter
Novelty:  0.00365806
Score:  0.751
Data Source:  STRINGDB
DDX53
Tbio
Family:  Enzyme
Novelty:  0.00106198
Score:  0.71
Data Source:  STRINGDB
SLC3A2
Tbio
Family:  Transporter
Novelty:  0.0021506
Score:  0.537
Data Source:  STRINGDB
SLC7A6
Tbio
Family:  Transporter
Novelty:  0.02732334
Score:  0.527
Data Source:  STRINGDB
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.49
Data Source:  STRINGDB
SLC16A10
Tbio
Family:  Transporter
Novelty:  0.02363735
Score:  0.466
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pappalysin‐1 measurement
1
2
2
89.6
eosinophil count
2
2
2
81.6
platelet count
1
2
2
71.4
1
1
1
51.7
eosinophil percentage of leukocytes
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pappalysin‐1 measurement
2
89.6
eosinophil count
2
81.6
platelet count
2
71.4
1
51.7
eosinophil percentage of leukocytes
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 43 member 1
706053
Mouse
MGI:1931352
72401
Rat
RGD:1308229
311168
Dog
solute carrier family 43 member 1
VGNC:46415
483493
Horse
solute carrier family 43 member 1
VGNC:23216
100066449
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 43 member 1
Mouse
Rat
Dog
solute carrier family 43 member 1
Horse
solute carrier family 43 member 1
Publication Statistics
PubMed Score 17.74
PubMed score by year
PubTator Score 13.06
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title