SLC43A1
Large neutral amino acids transporter small subunit 3
Protein Summary
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]
- ENST00000278426
- ENSP00000278426
- ENSG00000149150
- ENST00000528450
- ENSP00000435673
- LAT3
- PB39
- POV1
- LAT3
- PB39
- POV1
- R00504
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.89 | ||
PubMedID | 0.73 | ||
transcription factor binding site profile | 0.73 | ||
transcription factor | 0.63 | ||
histone modification site profile | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.74 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 97 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.74 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 97 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (21)
ZACN
Family: IC
Novelty: 0.21891621
p_int: 0.999264089
p_ni: 0.000003878
p_wrong: 0.000732033
Score: 0.189
Data Source: BioPlex,STRINGDB
SLC17A2
Family: Transporter
Novelty: 0.23941275
p_int: 0.847982483
p_ni: 0.000013123
p_wrong: 0.152004394
Score: 0.175
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amino acid transport across the plasma membrane | ||||
Reactome | SLC-mediated transmembrane transport | ||||
Reactome | Transport of inorganic cations/anions and amino acids/oligopeptides | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amino acid transport across the plasma membrane | ||||
SLC-mediated transmembrane transport | ||||
Transport of inorganic cations/anions and amino acids/oligopeptides | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (3)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
pappalysinâ1 measurement | 1 | 2 | 2 | 89.6 | |||||
eosinophil count | 2 | 2 | 2 | 81.6 | |||||
platelet count | 1 | 2 | 2 | 71.4 | |||||
1 | 1 | 1 | 51.7 | ||||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 49.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
pappalysinâ1 measurement | 2 | 89.6 | |||||
eosinophil count | 2 | 81.6 | |||||
platelet count | 2 | 71.4 | |||||
1 | 51.7 | ||||||
eosinophil percentage of leukocytes | 1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | solute carrier family 43 member 1 | 706053 | ||||||
Mouse | MGI:1931352 | 72401 | ||||||
Rat | RGD:1308229 | 311168 | ||||||
Dog | solute carrier family 43 member 1 | VGNC:46415 | 483493 | |||||
Horse | solute carrier family 43 member 1 | VGNC:23216 | 100066449 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | solute carrier family 43 member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 43 member 1 | |||||
Horse | solute carrier family 43 member 1 | |||||
Publication Statistics
PubMed Score 17.74
PubMed score by year
PubTator Score 13.06
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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