Tchem SLC40A1 Solute carrier family 40 member 1

Protein Summary

Description

May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NP59
• Q6FI62
• Q7Z4F8
• Q8IVB2
• Q9NRL0

Gene Name

• SLC40A1

Ensembl ID

• ENST00000261024
• ENSP00000261024
• ENSG00000138449

Symbol

• FPN1
• IREG1
• SLC11A3
• FPN1
• HFE4
• MTP1
• IREG1
• MST079
• MSTP079
• SLC11A3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.98
PubMedID	0.97
transcription factor perturbation	0.97
histone modification site profile	0.79
biological process	0.71

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc40 Iron Transporter / Solute Carrier Family 40 Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.34   (req: < 5)

Gene RIFs: 153   (req: <= 3)

Antibodies: 326   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.34   (req: >= 5)

Gene RIFs: 153   (req: > 3)

Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 182

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0