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Tchem
SLC40A1
Solute carrier family 40 member 1

Protein Summary
Description
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261024
  • ENSP00000261024
  • ENSG00000138449

Symbol
  • FPN1
  • IREG1
  • SLC11A3
  • FPN1
  • HFE4
  • MTP1
  • IREG1
  • MST079
  • MSTP079
  • SLC11A3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.98
PubMedID
0.97
transcription factor perturbation
0.97
histone modification site profile
0.79
biological process
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 465.06   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 465.06   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 182
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (182)
CHEMBL272552
Rendered image for CHEMBL272552
CHEMBL3393878
Rendered image for CHEMBL3393878
CHEMBL3393870
Rendered image for CHEMBL3393870
minihepcidin PR73
Rendered image for minihepcidin PR73
CHEMBL4564862
Rendered image for CHEMBL4564862
CHEMBL3393871
Rendered image for CHEMBL3393871
CHEMBL3393877
Rendered image for CHEMBL3393877
CHEMBL3393876
Rendered image for CHEMBL3393876
CHEMBL3393872
Rendered image for CHEMBL3393872
Protein-Protein Interactions (87)
HEPH
Tbio
Novelty:  0.00609103
Score:  0.989
Data Source:  Reactome,STRINGDB
CP
Tbio
Novelty:  0.00103285
Score:  0.986
Data Source:  Reactome,STRINGDB
HAMP
Tbio
Novelty:  0.00035828
Score:  0.965
Data Source:  STRINGDB
SLC11A2
Tchem
Family:  Transporter
Novelty:  0.00189409
Score:  0.913
Data Source:  STRINGDB
TFR2
Tbio
Family:  Enzyme
Novelty:  0.00480264
Score:  0.874
Data Source:  STRINGDB
HJV
Tbio
Novelty:  0.00495995
Score:  0.847
Data Source:  STRINGDB
CYBRD1
Tbio
Family:  Enzyme
Novelty:  0.01128708
Score:  0.842
Data Source:  STRINGDB
HFE
Tbio
Novelty:  0.00042077
Score:  0.84
Data Source:  STRINGDB
SLC39A1
Tbio
Family:  Transporter
Novelty:  0.00678191
Score:  0.814
Data Source:  STRINGDB
TFRC
Tbio
Novelty:  0.00025984
Score:  0.799
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Defective CP causes aceruloplasminemia (ACERULOP) (R-HSA-5619060)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective CP causes aceruloplasminemia (ACERULOP)
Reactome
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)
Reactome
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
Defective CP causes aceruloplasminemia (ACERULOP)
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)
Disease
Disorders of transmembrane transporters
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ferritin measurement
2
2
2
84.2
mean corpuscular hemoglobin concentration
2
2
2
74.1
hematocrit
2
2
2
61.8
liver iron measurement
1
2
2
54.3
red blood cell distribution width
2
1
2
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ferritin measurement
2
84.2
mean corpuscular hemoglobin concentration
2
74.1
hematocrit
2
61.8
liver iron measurement
2
54.3
red blood cell distribution width
2
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 40 member 1
VGNC:9060
459821
Macaque
solute carrier family 40 member 1
713321
Mouse
MGI:1315204
53945
Rat
RGD:620180
170840
Dog
solute carrier family 40 member 1
VGNC:46411
478837
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 40 member 1
Macaque
solute carrier family 40 member 1
Mouse
Rat
Dog
solute carrier family 40 member 1
Publication Statistics
PubMed Score 465.06
PubMed score by year
PubTator Score 219.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title