Tbio SLC39A8 Zinc transporter ZIP8

Protein Summary

Description

Acts as a manganese and zinc influx transporter (PubMed:12504855, PubMed:26637978). Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain (PubMed:26637978). This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q9C0K1
• B4E2H3
• Q96SM9
• Q9BVC0
• Q9NSA4

Gene Name

• SLC39A8

Ensembl ID

• ENST00000356736
• ENSP00000349174
• ENSG00000138821
• ENST00000394833
• ENSP00000378310
• ENST00000424970
• ENSP00000394548

Symbol

• BIGM103
• ZIP8
• ZIP8
• CDG2N
• PP3105
• BIGM103
• LZT-Hs6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.97
trait	0.93
gene perturbation	0.89
transcription factor binding site profile	0.87
histone modification site profile	0.81

Protein Classes

PANTHER Classes

Protein / Transporter / Zinc Transporter Zip8

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc39 Family Of Metal Ion Transporters / Zinc Transporter Zip8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.49   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.49   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0