You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC39A12
Zinc transporter ZIP12

Protein Summary
Description
Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia. Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377369
  • ENSP00000366586
  • ENSG00000148482
  • ENST00000377371
  • ENSP00000366588
  • ENST00000377374
  • ENSP00000366591
  • ENST00000539911
  • ENSP00000440445

Symbol
  • ZIP12
  • ZIP-12
  • LZT-Hs8
  • bA570F3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.47
cell type or tissue
0.46
trait
0.46
cellular component
0.44
molecular function
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.33   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.33   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (135)
FXYD6
Tbio
Family:  IC
Novelty:  0.0503209
p_int:  0.999919243
p_ni:  0.000028334
p_wrong:  0.000052423
Score:  0.254
Data Source:  BioPlex,STRINGDB
PODXL2
Tbio
Novelty:  0.09100487
p_int:  0.999867317
p_ni:  0.00013261
p_wrong:  7.2e-8
Data Source:  BioPlex
SELENOT
Tbio
Novelty:  0.02480242
p_int:  0.998702876
p_ni:  0.00129711
p_wrong:  1.4e-8
Data Source:  BioPlex
LETMD1
Tbio
Novelty:  0.02790517
p_int:  0.998289003
p_ni:  0.001710807
p_wrong:  1.9e-7
Data Source:  BioPlex
GJC1
Tbio
Novelty:  0.00375192
p_int:  0.997211309
p_ni:  0.001241488
p_wrong:  0.001547203
Data Source:  BioPlex
TLCD1
Tdark
Novelty:  0.76223034
p_int:  0.99554295
p_ni:  0.003096583
p_wrong:  0.001360467
Data Source:  BioPlex
GOLM1
Tbio
Novelty:  0.00752112
p_int:  0.995477822
p_ni:  0.004522094
p_wrong:  8.4e-8
Data Source:  BioPlex
SLC35B2
Tbio
Family:  Transporter
Novelty:  0.01516638
p_int:  0.995193402
p_ni:  0.004806595
p_wrong:  2e-9
Data Source:  BioPlex
HSD17B7
Tchem
Family:  Enzyme
Novelty:  0.04295724
p_int:  0.99517847
p_ni:  0.004642412
p_wrong:  0.000179118
Data Source:  BioPlex
SQLE
Tchem
Family:  Enzyme
Novelty:  0.0059338
p_int:  0.994541195
p_ni:  0.00545877
p_wrong:  3.6e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Zinc homeostasis
WikiPathways
Zinc homeostasis
WikiPathways
Zinc homeostasis
WikiPathways
Zinc homeostasis
WikiPathways
Nuclear Receptors Meta-Pathway
Name
Explore in Pharos
Explore in Source
Zinc homeostasis
Zinc homeostasis
Zinc homeostasis
Zinc homeostasis
Nuclear Receptors Meta-Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
2
2
1
26.9
88.6
leukocyte count
1
1
1
57.8
blood protein measurement
1
2
2
57.2
myeloid white cell count
1
1
1
56
neutrophil count
2
1
2
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
26.9
88.6
leukocyte count
1
57.8
blood protein measurement
2
57.2
myeloid white cell count
1
56
neutrophil count
2
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 12
VGNC:8885
739440
Macaque
solute carrier family 39 member 12
701128
Mouse
MGI:2139274
277468
Rat
RGD:1309305
291328
Dog
solute carrier family 39 member 12
VGNC:46401
477989
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 12
Macaque
solute carrier family 39 member 12
Mouse
Rat
Dog
solute carrier family 39 member 12
Publication Statistics
PubMed Score 13.33
PubMed score by year
PubTator Score 5.12
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title