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Tbio
SLC39A11
Zinc transporter ZIP11

Protein Summary
Description
Functions as a cellular zinc transporter.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255559
  • ENSP00000255559
  • ENSG00000133195
  • ENST00000542342
  • ENSP00000445829
  • ENST00000642526
  • ENSP00000496413
  • ENSG00000285189
  • ENST00000645633
  • ENSP00000494287

Symbol
  • C17orf26
  • ZIP11
  • ZIP11
  • ZIP-11
  • C17orf26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
phenotype
0.8
histone modification site profile
0.78
transcription factor binding site profile
0.78
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.35   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.35   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
IZUMO1
Tbio
Novelty:  0.01839953
p_int:  0.999994245
p_ni:  0.000005755
Data Source:  BioPlex
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.998098712
p_ni:  0.001901288
Data Source:  BioPlex
FAM174A
Tdark
Novelty:  0.30693139
p_int:  0.997942812
p_ni:  0.002057188
Data Source:  BioPlex
CD274
Tclin
Novelty:  0.00013449
p_int:  0.996589886
p_ni:  0.003410114
Data Source:  BioPlex
WBP1
Tbio
Novelty:  1.24967974
p_int:  0.994522626
p_ni:  0.005477374
p_wrong:  1e-9
Data Source:  BioPlex
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.992654216
p_ni:  0.007345784
Data Source:  BioPlex
PVRIG
Tbio
Novelty:  0.28920924
p_int:  0.982524384
p_ni:  0.017475616
Data Source:  BioPlex
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.979568455
p_ni:  0.020431545
Data Source:  BioPlex
SIGLEC12
Tbio
Novelty:  0.00914453
p_int:  0.97170951
p_ni:  0.02829049
Score:  0.183
Data Source:  BioPlex,STRINGDB
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
p_int:  0.968930321
p_ni:  0.031069645
p_wrong:  3.4e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Zinc homeostasis
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
NRF2 pathway
Name
Explore in Pharos
Explore in Source
Zinc homeostasis
Nuclear Receptors Meta-Pathway
NRF2 pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
61.4
1
1
0
1.1
48.5
2
1
2
46.9
red blood cell distribution width
1
1
1
8.3
BMI-adjusted hip circumference
1
1
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
61.4
0
1.1
48.5
2
46.9
red blood cell distribution width
1
8.3
BMI-adjusted hip circumference
1
0.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 11
VGNC:9623
454853
Macaque
solute carrier family 39 member 11
695406
Mouse
MGI:1917056
69806
Rat
RGD:1311981
287796
Dog
solute carrier family 39 member 11
106559224
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 11
Macaque
solute carrier family 39 member 11
Mouse
Rat
Dog
solute carrier family 39 member 11
Publication Statistics
PubMed Score 10.35
PubMed score by year
PubTator Score 3.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title