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Tbio
SLC39A1
Zinc transporter ZIP1

Protein Summary
Description
Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells. This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310483
  • ENSP00000309710
  • ENSG00000143570
  • ENST00000356205
  • ENSP00000348535
  • ENST00000368621
  • ENSP00000357610
  • ENST00000368623
  • ENSP00000357612
  • ENST00000617697
  • ENSP00000479421
  • ENST00000621013
  • ENSP00000484182

Symbol
  • IRT1
  • ZIP1
  • ZIRTL
  • ZIP1
  • ZIRTL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
transcription factor binding site profile
0.74
tissue sample
0.71
histone modification site profile
0.68
cell type or tissue
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.2   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.2   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.995463427
p_ni:  0.00453378
p_wrong:  0.000002793
Data Source:  BioPlex
SCARA3
Tbio
Novelty:  0.00621523
p_int:  0.985643445
p_ni:  0.014356487
p_wrong:  6.9e-8
Data Source:  BioPlex
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.983554759
p_ni:  0.016445193
p_wrong:  4.8e-8
Data Source:  BioPlex
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.981419351
p_ni:  0.018580575
p_wrong:  7.4e-8
Score:  0.231
Data Source:  BioPlex,STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.980189571
p_ni:  0.019810191
p_wrong:  2.39e-7
Data Source:  BioPlex
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.979902106
p_ni:  0.020097862
p_wrong:  3.2e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
NME2P1
Tdark
Family:  Kinase
p_int:  0.978860189
p_ni:  0.021139806
p_wrong:  5e-9
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.976995305
p_ni:  0.023004583
p_wrong:  1.12e-7
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.975045118
p_ni:  0.024954882
Data Source:  BioPlex
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.974700007
p_ni:  0.025299796
p_wrong:  1.97e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Metal ion SLC transporters (R-HSA-425410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metal ion SLC transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Reactome
Zinc influx into cells by the SLC39 gene family
Name
Explore in Pharos
Explore in Source
Metal ion SLC transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Zinc influx into cells by the SLC39 gene family
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first birth measurement
2
2
2
84.9
C-reactive protein measurement
2
3
3
84.2
platelet count
2
2
2
75.2
neuroimaging measurement
5
4
5
70.6
mathematical ability
2
1
2
65.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first birth measurement
2
84.9
C-reactive protein measurement
3
84.2
platelet count
2
75.2
neuroimaging measurement
5
70.6
mathematical ability
2
65.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 1
VGNC:8112
457340
Macaque
solute carrier family 39 member 1
715994
Mouse
MGI:1353474
30791
Rat
RGD:1305241
361986
Dog
solute carrier family 39 member 1
VGNC:46400
100855713
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 1
Macaque
solute carrier family 39 member 1
Mouse
Rat
Dog
solute carrier family 39 member 1
Publication Statistics
PubMed Score 178.20
PubMed score by year
PubTator Score 59.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title