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Tbio
SLC38A2
Sodium-coupled neutral amino acid transporter 2

Protein Summary
Description
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256689
  • ENSP00000256689
  • ENSG00000134294
  • ENST00000612232
  • ENSP00000482873

Symbol
  • ATA2
  • KIAA1382
  • SAT2
  • SNAT2
  • ATA2
  • SAT2
  • SNAT2
  • PRO1068
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
PubMedID
0.88
cell type or tissue
0.78
microRNA
0.77
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.4   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.4   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.967093119
p_ni:  0.03290649
p_wrong:  3.91e-7
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.854260917
p_ni:  0.145739083
Score:  0.165
Data Source:  BioPlex,STRINGDB
LPAR6
Tchem
Family:  GPCR
Novelty:  0.01801122
p_int:  0.848628252
p_ni:  0.151371748
Score:  0.189
Data Source:  BioPlex,STRINGDB
DLK1
Tchem
Novelty:  0.00212394
p_int:  0.81738252
p_ni:  0.18261748
Score:  0.189
Data Source:  BioPlex,STRINGDB
DACT3
Tbio
Novelty:  0.04684884
p_int:  0.786307522
p_ni:  0.213692477
p_wrong:  2e-9
Data Source:  BioPlex
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.876
Data Source:  STRINGDB
SLC38A1
Tbio
Family:  Transporter
Novelty:  0.01350134
Score:  0.822
Data Source:  STRINGDB
SLC1A5
Tchem
Family:  Transporter
Novelty:  0.00201741
Score:  0.815
Data Source:  STRINGDB
SLC1A4
Tbio
Family:  Transporter
Novelty:  0.01334316
Score:  0.798
Data Source:  STRINGDB
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
Score:  0.793
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (50)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Glutamate Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
SLC-mediated transmembrane transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
2
2
69.1
eosinophil percentage of leukocytes
1
1
1
10.3
eosinophil count
1
1
1
7.9
electrocardiography
1
1
2
7.6
hair color
1
1
0
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
69.1
eosinophil percentage of leukocytes
1
10.3
eosinophil count
1
7.9
electrocardiography
2
7.6
hair color
0
1
6.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 38 member 2
VGNC:8540
451851
Macaque
solute carrier family 38 member 2
702253
Mouse
MGI:1915010
67760
Rat
RGD:69420
29642
Dog
solute carrier family 38 member 2
VGNC:46393
486596
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 38 member 2
Macaque
solute carrier family 38 member 2
Mouse
Rat
Dog
solute carrier family 38 member 2
Publication Statistics
PubMed Score 142.40
PubMed score by year
PubTator Score 73.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title