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Tbio
SLC38A1
Sodium-coupled neutral amino acid transporter 1

Protein Summary
Description
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398637
  • ENSP00000381634
  • ENSG00000111371
  • ENST00000439706
  • ENSP00000398142
  • ENST00000546893
  • ENSP00000447853
  • ENST00000549049
  • ENSP00000449607

Symbol
  • ATA1
  • NAT2
  • SAT1
  • SNAT1
  • ATA1
  • NAT2
  • SAT1
  • SNAT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.9
microRNA
0.9
kinase perturbation
0.88
molecular function
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.71   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.71   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
SLC38A2
Tbio
Family:  Transporter
Novelty:  0.00808235
Score:  0.822
Data Source:  STRINGDB
SLC1A5
Tchem
Family:  Transporter
Novelty:  0.00201741
Score:  0.76
Data Source:  STRINGDB
SCN11A
Tclin
Family:  IC
Novelty:  0.00145294
Score:  0.749
Data Source:  STRINGDB
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.739
Data Source:  STRINGDB
SLC7A5
Tchem
Family:  Transporter
Novelty:  0.00365806
Score:  0.734
Data Source:  STRINGDB
PBX2
Tbio
Family:  TF
Novelty:  0.01339291
Score:  0.712
Data Source:  STRINGDB
AANAT
Tbio
Family:  Enzyme
Novelty:  0.0039709
Score:  0.681
Data Source:  STRINGDB
SLC1A4
Tbio
Family:  Transporter
Novelty:  0.01334316
Score:  0.678
Data Source:  STRINGDB
GCC1
Tbio
Novelty:  0.0844824
Score:  0.656
Data Source:  STRINGDB
SLC7A8
Tbio
Family:  Transporter
Novelty:  0.03433454
Score:  0.653
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Amino acid transport across the plasma membrane (R-HSA-352230)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Astrocytic Glutamate-Glutamine Uptake And Metabolism
Reactome
Neuronal System
Reactome
Neurotransmitter uptake and metabolism In glial cells
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Astrocytic Glutamate-Glutamine Uptake And Metabolism
Neuronal System
Neurotransmitter uptake and metabolism In glial cells
SLC-mediated transmembrane transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
68.8
eosinophil count
2
2
2
50.5
birth weight
1
1
1
35
hair color
1
1
0
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
68.8
eosinophil count
2
50.5
birth weight
1
35
hair color
0
1
6.9
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 38 member 1
VGNC:8539
451850
Macaque
solute carrier family 38 member 1
702135
Mouse
MGI:2145895
105727
Rat
RGD:69645
170567
Dog
solute carrier family 38 member 1
VGNC:46390
477633
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 38 member 1
Macaque
solute carrier family 38 member 1
Mouse
Rat
Dog
solute carrier family 38 member 1
Publication Statistics
PubMed Score 78.71
PubMed score by year
PubTator Score 38.07
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title