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Tdark
SLC37A3
Sugar phosphate exchanger 3

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326232
  • ENSP00000321498
  • ENSG00000157800
  • ENST00000340308
  • ENSP00000343358
  • ENST00000447932
  • ENSP00000397481

Symbol
  • SPX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.74
transcription factor perturbation
0.68
transcription factor
0.62
tissue
0.52
microRNA
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
SPRYD7
Tdark
Novelty:  0.25334319
p_int:  0.999369491
p_ni:  0.000408544
p_wrong:  0.000221965
Score:  0.188
Data Source:  BioPlex,STRINGDB
ATRAID
Tbio
Novelty:  0.05036748
p_int:  0.999343545
p_ni:  0.000507232
p_wrong:  0.000149223
Score:  0.7
Data Source:  BioPlex,STRINGDB
CAV1
Tbio
Novelty:  0.00035244
p_int:  0.986878408
p_ni:  0.004906008
p_wrong:  0.008215583
Data Source:  BioPlex
CLTCL1
Tbio
Novelty:  0.05667807
p_int:  0.955580678
p_ni:  0.044419322
Data Source:  BioPlex
APOB
Tchem
Novelty:  0.00008247
p_int:  0.934312432
p_ni:  0.065684641
p_wrong:  0.000002926
Data Source:  BioPlex
SLC25A46
Tbio
Family:  Transporter
Novelty:  0.02720146
p_int:  0.918652189
p_ni:  0.081337493
p_wrong:  0.000010318
Data Source:  BioPlex
MTX3
Tdark
Novelty:  0.06082176
p_int:  0.905735496
p_ni:  0.094264503
Data Source:  BioPlex
RNASEL
Tchem
Family:  Kinase
Novelty:  0.00165549
p_int:  0.898579831
p_ni:  0.072335545
p_wrong:  0.029084624
Score:  0.268
Data Source:  BioPlex,STRINGDB
TUBGCP2
Tbio
Novelty:  0.01856674
p_int:  0.895785405
p_ni:  0.104214595
Score:  0.151
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.891522048
p_ni:  0.108477952
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
1
1
59
balding measurement
1
1
1
56.2
risky sexual behaviour measurement
1
1
1
45.2
glomerular filtration rate
1
1
1
33.1
risk-taking behaviour
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
59
balding measurement
1
56.2
risky sexual behaviour measurement
1
45.2
glomerular filtration rate
1
33.1
risk-taking behaviour
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 37 member 3
VGNC:14089
472534
Mouse
MGI:1919394
72144
Rat
RGD:1310346
312255
Dog
solute carrier family 37 member 3
VGNC:46388
482768
Horse
solute carrier family 37 member 3
VGNC:23186
100065965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 37 member 3
Mouse
Rat
Dog
solute carrier family 37 member 3
Horse
solute carrier family 37 member 3
Publication Statistics
PubMed Score 6.02
PubMed score by year
PubTator Score 1.78
PubTator score by year
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Related Publications
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PMID
Year
Title