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Tbio
SLC37A2
Glucose-6-phosphate exchanger SLC37A2

Protein Summary
Description
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308074
  • ENSP00000311833
  • ENSG00000134955
  • ENST00000403796
  • ENSP00000384407

Symbol
  • pp11662
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
cell type or tissue
0.68
transcription factor perturbation
0.61
transcription factor binding site profile
0.6
tissue sample
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.83   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.83   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
BAG6
Tbio
Novelty:  0.0035578
Score:  0.806
Data Source:  STRINGDB
UAP1
Tbio
Family:  Enzyme
Novelty:  0.02034314
Score:  0.74
Data Source:  STRINGDB
UAP1L1
Tdark
Family:  Enzyme
Novelty:  0.36065169
Score:  0.74
Data Source:  STRINGDB
GART
Tclin
Novelty:  0.00524985
Score:  0.687
Data Source:  STRINGDB
SLC17A9
Tchem
Family:  Transporter
Novelty:  0.01934725
Score:  0.675
Data Source:  STRINGDB
SPX
Tbio
Novelty:  0.00488569
Score:  0.656
Data Source:  STRINGDB
IER3
Tbio
Novelty:  0.00813318
Score:  0.626
Data Source:  STRINGDB
SLC20A1
Tbio
Family:  Transporter
Novelty:  0.01123373
Score:  0.589
Data Source:  STRINGDB
SLC15A3
Tbio
Family:  Transporter
Novelty:  0.02161979
Score:  0.587
Data Source:  STRINGDB
SLC35A3
Tbio
Family:  Transporter
Novelty:  0.02472244
Score:  0.567
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
63.6
1
1
0
1.3
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
63.6
0
1.3
49.5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 37 member 2
VGNC:7747
451643
Mouse
MGI:1929693
56857
Rat
RGD:1564160
500973
Dog
solute carrier family 37 member 2
VGNC:46387
489303
Horse
solute carrier family 37 member 2
VGNC:23185
100072304
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 37 member 2
Mouse
Rat
Dog
solute carrier family 37 member 2
Horse
solute carrier family 37 member 2
Publication Statistics
PubMed Score 13.83
PubMed score by year
PubTator Score 3.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title