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Tchem
SLC34A1
Sodium-dependent phosphate transport protein 2A

Protein Summary
Description
Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324417
  • ENSP00000321424
  • ENSG00000131183
  • ENST00000512593
  • ENSP00000423022

Symbol
  • NPT2
  • SLC17A2
  • NPT2
  • FRTS2
  • SLC11
  • HCINF2
  • NAPI-3
  • NPTIIa
  • NPHLOP1
  • SLC17A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
molecular function
0.76
cellular component
0.66
cell type or tissue
0.61
tissue sample
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.58   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.58   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0