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Tchem
SLC33A1
Acetyl-coenzyme A transporter 1

Protein Summary
Description
Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:9096318). Negatively regulates BMP signaling (PubMed:25402622). The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359479
  • ENSP00000352456
  • ENSG00000169359
  • ENST00000392845
  • ENSP00000376587
  • ENST00000643144
  • ENSP00000496241

Symbol
  • ACATN
  • AT1
  • AT1
  • AT-1
  • ACATN
  • SPG42
  • CCHLND
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
transcription factor binding site profile
0.92
transcription factor
0.76
tissue sample
0.75
microRNA
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.2   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.2   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 143
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (143)
US8592431, 167
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US8592431, 135
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US8592431, 147
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US8592431, 264
Rendered image for US8592431, 264
CHEMBL3648551
Rendered image for CHEMBL3648551
US8592431, 354
Rendered image for US8592431, 354
US8592431, 376
Rendered image for US8592431, 376
US8592431, 2
Rendered image for US8592431, 2
US8592431, 117
Rendered image for US8592431, 117
US8592431, 134
Rendered image for US8592431, 134
Protein-Protein Interactions (104)
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.808221206
p_ni:  0.191778794
Score:  0.202
Data Source:  BioPlex,STRINGDB
RBM42
Tdark
Novelty:  0.37655036
p_int:  0.792382862
p_ni:  0.207182727
p_wrong:  0.000434411
Score:  0.208
Data Source:  BioPlex,STRINGDB
B4GALNT1
Tbio
Family:  Enzyme
Novelty:  0.01060447
Score:  0.937
Data Source:  STRINGDB
ST8SIA5
Tdark
Family:  Enzyme
Novelty:  0.19468906
Score:  0.908
Data Source:  STRINGDB
ST8SIA1
Tbio
Family:  Enzyme
Novelty:  0.02322808
Score:  0.9
Data Source:  STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.89
Data Source:  STRINGDB
DNAJB9
Tbio
Novelty:  0.00536296
Score:  0.86
Data Source:  STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
Score:  0.858
Data Source:  STRINGDB
DNAJC3
Tbio
Novelty:  0.02129782
Score:  0.827
Data Source:  STRINGDB
SEC63
Tbio
Novelty:  0.00974614
Score:  0.694
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Defective SLC33A1 causes spastic paraplegia 42 (SPG42) (R-HSA-5619061)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC33A1 causes spastic paraplegia 42 (SPG42)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Defective SLC33A1 causes spastic paraplegia 42 (SPG42)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
SLC-mediated transmembrane transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
57.6
1
1
0
6.8
50.6
serum alanine aminotransferase measurement
2
2
1
5.8
50.6
alkaline phosphatase measurement
1
1
0
6.3
42.3
total cholesterol measurement
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
57.6
0
6.8
50.6
serum alanine aminotransferase measurement
1
5.8
50.6
alkaline phosphatase measurement
0
6.3
42.3
total cholesterol measurement
1
36.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 33 member 1
VGNC:8004
460796
Mouse
MGI:1332247
11416
Rat
RGD:620653
64018
Dog
solute carrier family 33 member 1
VGNC:46357
485724
Horse
solute carrier family 33 member 1
VGNC:23158
100051998
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 33 member 1
Mouse
Rat
Dog
solute carrier family 33 member 1
Horse
solute carrier family 33 member 1
Publication Statistics
PubMed Score 17.20
PubMed score by year
PubTator Score 11.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title