Tbio SLC30A8 Zinc transporter 8

Protein Summary

Description

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q8IWU4
• A0AVP9
• A5YM39
• B4DPE0
• Q8TCL3
• ZnT-8

Gene Name

• SLC30A8

Ensembl ID

• ENST00000427715
• ENSP00000407505
• ENSG00000164756
• ENST00000456015
• ENSP00000415011
• ENST00000519688
• ENSP00000431069
• ENST00000521243
• ENSP00000428545

Symbol

• ZNT8
• ZNT8
• ZnT-8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.97
cell type or tissue	0.9
microRNA	0.89
biological process	0.8
biological term	0.79

Protein Classes

PANTHER Classes

Protein / Transporter / Zinc Transporter 8

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc30 Zinc Transporter Family / Zinc Transporter 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.75   (req: < 5)

Gene RIFs: 152   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 311.75   (req: >= 5)

Gene RIFs: 152   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0