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Tbio
SLC30A10
Zinc transporter 10

Protein Summary
Description
Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death (PubMed:22341972, PubMed:22341971, PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356609
  • ENSP00000349018
  • ENSG00000196660
  • ENST00000366926
  • ENSP00000355893

Symbol
  • ZNT10
  • ZNT8
  • ZNT8
  • ZRC1
  • HMDPC
  • ZNT10
  • ZnT-10
  • HMNDYT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
transcription factor perturbation
0.68
PubMedID
0.61
transcription factor binding site profile
0.61
histone modification site profile
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.37   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.37   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
PTPRN
Tbio
Family:  Enzyme
Novelty:  0.00076479
Score:  0.908
Data Source:  STRINGDB
SLC39A14
Tbio
Family:  Transporter
Novelty:  0.01053215
Score:  0.839
Data Source:  STRINGDB
SLC39A7
Tbio
Family:  Transporter
Novelty:  0.01746862
Score:  0.835
Data Source:  STRINGDB
SLC30A6
Tbio
Family:  Transporter
Novelty:  0.06083299
Score:  0.825
Data Source:  STRINGDB
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
Score:  0.817
Data Source:  STRINGDB
SLC30A9
Tbio
Family:  Transporter
Novelty:  0.07156604
Score:  0.805
Data Source:  STRINGDB
GAD2
Tbio
Family:  Enzyme
Novelty:  0.00058427
Score:  0.799
Data Source:  STRINGDB
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
Score:  0.798
Data Source:  STRINGDB
SLC39A1
Tbio
Family:  Transporter
Novelty:  0.00678191
Score:  0.785
Data Source:  STRINGDB
SLC39A8
Tbio
Family:  Transporter
Novelty:  0.00923197
Score:  0.777
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metal ion SLC transporters (R-HSA-425410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metal ion SLC transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Metal ion SLC transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
2
16
18
98
BMI-adjusted hip circumference
2
22
24
98
heel bone mineral density
3
7
12
97.4
BMI-adjusted waist-hip ratio
1
5
5
95.7
waist-hip ratio
1
5
5
95.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
18
98
BMI-adjusted hip circumference
24
98
heel bone mineral density
12
97.4
BMI-adjusted waist-hip ratio
5
95.7
waist-hip ratio
5
95.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 10
VGNC:6125
469681
Mouse
MGI:2685058
226781
Rat
RGD:1305098
289353
Dog
solute carrier family 30 member 10
VGNC:53131
488599
Horse
solute carrier family 30 member 10
VGNC:23146
100050310
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 10
Mouse
Rat
Dog
solute carrier family 30 member 10
Horse
solute carrier family 30 member 10
Publication Statistics
PubMed Score 229.37
PubMed score by year
PubTator Score 36.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title