SLC30A10
Zinc transporter 10
Protein Summary
Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death (PubMed:22341972, PubMed:22341971, PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of ...more
- ENST00000356609
- ENSP00000349018
- ENSG00000196660
- ENST00000366926
- ENSP00000355893
- ZNT10
- ZNT8
- ZNT8
- ZRC1
- HMDPC
- ZNT10
- ZnT-10
- HMNDYT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.78 | ||
transcription factor perturbation | 0.68 | ||
PubMedID | 0.61 | ||
transcription factor binding site profile | 0.61 | ||
histone modification site profile | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 229.37 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 105 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 229.37 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 105 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (94)
Nearest Tclin Targets
Pathways (5)
Reactome (4)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metal ion SLC transporters | ||||
Reactome | SLC-mediated transmembrane transport | ||||
Reactome | Transport of bile salts and organic acids, metal ions and amine compounds | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metal ion SLC transporters | ||||
SLC-mediated transmembrane transport | ||||
Transport of bile salts and organic acids, metal ions and amine compounds | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (1)
Components (5)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hip circumference | 2 | 16 | 18 | 98 | |||||
BMI-adjusted hip circumference | 2 | 22 | 24 | 98 | |||||
heel bone mineral density | 3 | 7 | 12 | 97.4 | |||||
BMI-adjusted waist-hip ratio | 1 | 5 | 5 | 95.7 | |||||
waist-hip ratio | 1 | 5 | 5 | 95.6 | |||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hip circumference | 18 | 98 | |||||
BMI-adjusted hip circumference | 24 | 98 | |||||
heel bone mineral density | 12 | 97.4 | |||||
BMI-adjusted waist-hip ratio | 5 | 95.7 | |||||
waist-hip ratio | 5 | 95.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 30 member 10 | VGNC:6125 | 469681 | |||||
Mouse | MGI:2685058 | 226781 | ||||||
Rat | RGD:1305098 | 289353 | ||||||
Dog | solute carrier family 30 member 10 | VGNC:53131 | 488599 | |||||
Horse | solute carrier family 30 member 10 | VGNC:23146 | 100050310 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 30 member 10 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 30 member 10 | |||||
Horse | solute carrier family 30 member 10 | |||||
Publication Statistics
PubMed Score 229.37
PubMed score by year
PubTator Score 36.42
PubTator score by year
Related Publications
Text Mined References (24)
GeneRif Annotations (18)
Items per page:
0 of 0
PMID | Year | Title |
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