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Tbio
SLC30A1
Zinc transporter 1

Protein Summary
Description
May be involved in zinc transport out of the cell.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367001
  • ENSP00000355968
  • ENSG00000170385

Symbol
  • ZNT1
  • ZNT1
  • ZRC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.94
small molecule perturbation
0.85
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.55   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.55   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
XXYLT1
Tbio
Family:  Enzyme
Novelty:  0.16837376
p_int:  0.999990332
p_ni:  0.000009668
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999921278
p_ni:  0.000078722
Data Source:  BioPlex
CD83
Tbio
Novelty:  0.00138653
p_int:  0.999918311
p_ni:  0.000081689
Data Source:  BioPlex
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.999842011
p_ni:  0.000157988
p_wrong:  1e-9
Score:  0.284
Data Source:  BioPlex,STRINGDB
CSGALNACT1
Tbio
Family:  Enzyme
Novelty:  0.03463325
p_int:  0.999841512
p_ni:  0.000158485
p_wrong:  3e-9
Score:  0.669
Data Source:  BioPlex,STRINGDB
RAMP1
Tclin
Novelty:  0.00831253
p_int:  0.99970964
p_ni:  0.000290341
p_wrong:  1.9e-8
Data Source:  BioPlex
METTL9
Tdark
Family:  Enzyme
Novelty:  0.20589257
p_int:  0.999342556
p_ni:  0.000657432
p_wrong:  1.1e-8
Data Source:  BioPlex
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.999085734
p_ni:  0.000912196
p_wrong:  0.00000207
Data Source:  BioPlex
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.997905299
p_ni:  0.002094701
Data Source:  BioPlex
GALNT6
Tbio
Family:  Enzyme
Novelty:  0.04627605
p_int:  0.99781235
p_ni:  0.002187649
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Metal ion SLC transporters (R-HSA-425410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metal ion SLC transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Reactome
Zinc efflux and compartmentalization by the SLC30 family
Name
Explore in Pharos
Explore in Source
Metal ion SLC transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Zinc efflux and compartmentalization by the SLC30 family
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
5
5
96
alkaline phosphatase measurement
2
1
1
7
73.6
mean corpuscular hemoglobin concentration
1
1
1
12.7
1
1
0
1.2
4.8
self reported educational attainment
1
1
1
2.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
96
alkaline phosphatase measurement
1
7
73.6
mean corpuscular hemoglobin concentration
1
12.7
0
1.2
4.8
self reported educational attainment
1
2.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 30 member 1
711624
Mouse
MGI:1345281
22782
Rat
RGD:61918
58976
Dog
solute carrier family 30 member 1
VGNC:46346
100286799
Cow
solute carrier family 30 member 1
VGNC:34805
522265
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 30 member 1
Mouse
Rat
Dog
solute carrier family 30 member 1
Cow
solute carrier family 30 member 1
Publication Statistics
PubMed Score 201.55
PubMed score by year
PubTator Score 74.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title