Tchem SLC2A2 Solute carrier family 2, facilitated glucose transporter member 2

Protein Summary

Description

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• P11168
• A8K481
• B2R936
• B7Z547
• F8W8V8
• Q9UCW9

Gene Name

• SLC2A2

Ensembl ID

• ENST00000314251
• ENSP00000323568
• ENSG00000163581

Symbol

• GLUT2
• GLUT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
chemical	0.67
gene perturbation	0.67
microRNA	0.65
cell type or tissue	0.63

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc2 Family Of Hexose And Sugar Alcohol Transporters / Class I Transporters / Solute Carrier Family 2, Facilitated Glucose Transporter Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 991.68   (req: < 5)

Gene RIFs: 71   (req: <= 3)

Antibodies: 428   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 991.68   (req: >= 5)

Gene RIFs: 71   (req: > 3)

Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0