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Tbio
SLC2A14
Solute carrier family 2, facilitated glucose transporter member 14

Protein Summary
Description
Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis. Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340749
  • ENSP00000340450
  • ENSG00000173262
  • ENST00000396589
  • ENSP00000379834
  • ENST00000431042
  • ENSP00000407287
  • ENST00000535295
  • ENSP00000440492
  • ENST00000539924
  • ENSP00000445929
  • ENST00000542505
  • ENSP00000438484
  • ENST00000542546
  • ENSP00000443903
  • ENST00000543909
  • ENSP00000440480
  • ENST00000616981
  • ENSP00000482927

Symbol
  • GLUT14
  • GLUT3
  • GLUT14
  • SLC2A3P3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell line
0.68
tissue sample
0.65
tissue
0.52
cell type or tissue
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 371.88   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 371.88   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
SLC2A3
Tchem
Family:  Transporter
Novelty:  0.00229395
p_int:  1
Score:  0.902
Data Source:  BioPlex,STRINGDB
EPN1
Tbio
Novelty:  0.01788784
p_int:  0.998045393
p_ni:  0.001954607
Score:  0.198
Data Source:  BioPlex,STRINGDB
HBB
Tbio
Novelty:  0.00049683
p_int:  0.996800161
p_ni:  0.003167198
p_wrong:  0.000032641
Score:  0.183
Data Source:  BioPlex,STRINGDB
HBA1
Tclin
Novelty:  0.00094113
p_int:  0.961298347
p_ni:  0.038699993
p_wrong:  0.00000166
Data Source:  BioPlex
SMAP2
Tbio
Novelty:  0.70006863
p_int:  0.894296993
p_ni:  0.105695702
p_wrong:  0.000007305
Score:  0.188
Data Source:  BioPlex,STRINGDB
WDR73
Tbio
Novelty:  0.10253438
p_int:  0.799900731
p_ni:  0.200091945
p_wrong:  0.000007324
Score:  0.345
Data Source:  BioPlex,STRINGDB
PPARGC1A
Tbio
Novelty:  0.0003625
Score:  0.908
Data Source:  STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
Score:  0.902
Data Source:  STRINGDB
MEF2D
Tbio
Family:  TF
Novelty:  0.00732653
Score:  0.9
Data Source:  STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cellular hexose transport (R-HSA-189200)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular hexose transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Cellular hexose transport
SLC-mediated transmembrane transport
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
4
62.1
mean platelet volume
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
4
62.1
mean platelet volume
1
27.3
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 14
VGNC:13446
748311
Mouse
MGI:95757
20527
Rat
RGD:3706
25551
Dog
solute carrier family 2 member 3
403997
Horse
solute carrier family 2 member 3
100053371
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 14
Mouse
Rat
Dog
solute carrier family 2 member 3
Horse
solute carrier family 2 member 3
Publication Statistics
PubMed Score 371.88
PubMed score by year
PubTator Score 16.38
PubTator score by year
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Related Publications
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0 of 0
PMID
Text