SLC2A1
Solute carrier family 2, facilitated glucose transporter member 1
Protein Summary
Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013]
- ENST00000426263
- ENSP00000416293
- ENSG00000117394
- GLUT1
- CSE
- PED
- DYT9
- GLUT
- DYT17
- DYT18
- EIG12
- GLUT1
- HTLVR
- GLUT-1
- SDCHCN
- GLUT1DS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
cellular component | 0.98 | ||
transcription factor perturbation | 0.97 | ||
chemical | 0.96 | ||
interacting protein | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4127.85 (req: < 5)
Gene RIFs: 598 (req: <= 3)
Antibodies: 625 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4127.85 (req: >= 5)
Gene RIFs: 598 (req: > 3)
Antibodies: 625 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 126
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0