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Tbio
SLC27A6
Long-chain fatty acid transport protein 6

Protein Summary
Description
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart. This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262462
  • ENSP00000262462
  • ENSG00000113396
  • ENST00000395266
  • ENSP00000378684
  • ENST00000506176
  • ENSP00000421024

Symbol
  • ACSVL2
  • FACVL2
  • FATP1
  • FATP6
  • ACSVL2
  • FACVL2
  • VLCS-H1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.6
protein domain
0.58
tissue
0.55
tissue sample
0.52
small molecule perturbation
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.15   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.15   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
p_int:  0.999481674
p_ni:  0.000518324
p_wrong:  2e-9
Data Source:  BioPlex
WDR41
Tbio
Novelty:  0.20400077
p_int:  0.999205976
p_ni:  0.000773728
p_wrong:  0.000020296
Score:  0.187
Data Source:  BioPlex,STRINGDB
UST
Tbio
Family:  Enzyme
Novelty:  0.03897672
p_int:  0.999039151
p_ni:  0.000960849
Score:  0.179
Data Source:  BioPlex,STRINGDB
HFE
Tbio
Novelty:  0.00042077
p_int:  0.998990306
p_ni:  0.001009694
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.994920331
p_ni:  0.005079669
Data Source:  BioPlex
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.99421598
p_ni:  0.00578402
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.971972113
p_ni:  0.028027887
Data Source:  BioPlex
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.924815403
p_ni:  0.075184597
Data Source:  BioPlex
PCDHGB2
Tdark
Novelty:  1.16587709
p_int:  0.918637704
p_ni:  0.081362296
Data Source:  BioPlex
PCDHA8
Tdark
Novelty:  0.57189179
p_int:  0.915425864
p_ni:  0.084572606
p_wrong:  0.00000153
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (35)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of fatty acids
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of fatty acids
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
4
93.6
testosterone measurement
3
3
3
81.4
BMI-adjusted hip circumference
1
2
2
67.5
Diuretic use measurement
1
1
1
62.8
Agents acting on the renin-angiotensin system use measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
93.6
testosterone measurement
3
81.4
BMI-adjusted hip circumference
2
67.5
Diuretic use measurement
1
62.8
Agents acting on the renin-angiotensin system use measurement
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 27 member 6
VGNC:8640
462038
Macaque
solute carrier family 27 member 6
705005
Mouse
MGI:3036230
225579
Dog
solute carrier family 27 member 6
VGNC:46333
474666
Horse
solute carrier family 27 member 6
VGNC:23134
100063461
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 27 member 6
Macaque
solute carrier family 27 member 6
Mouse
Dog
solute carrier family 27 member 6
Horse
solute carrier family 27 member 6
Publication Statistics
PubMed Score 78.15
PubMed score by year
PubTator Score 6.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title