Tbio SLC27A5 Bile acyl-CoA synthetase

Protein Summary

Description

Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y2P5
• B3KVP6
• B4DPQ1
• BACS

Gene Name

• SLC27A5

Ensembl ID

• ENST00000263093
• ENSP00000263093
• ENSG00000083807
• ENST00000601355
• ENSP00000470368

Symbol

• ACSB
• ACSVL6
• FACVL3
• FATP5
• BAL
• ACSB
• BACS
• FATP5
• ACSVL6
• FACVL3
• FATP-5
• VLACSR
• VLCSH2
• VLCS-H2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
cellular component	0.73
kinase perturbation	0.66
cell type or tissue	0.63
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Ligase / Bile Acyl-coa Synthetase

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc27 Family Of Fatty Acid Transporters / Bile Acyl-coa Synthetase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.86   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 279   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.86   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0