Tchem SLC27A4 Long-chain fatty acid transport protein 4

Protein Summary

Description

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity). This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q6P1M0
• A8K2F7
• O95186
• Q96G53
• FATP-4

Gene Name

• SLC27A4

Ensembl ID

• ENST00000300456
• ENSP00000300456
• ENSG00000167114
• ENST00000372870
• ENSP00000361961

Symbol

• ACSVL4
• FATP4
• IPS
• FATP4
• ACSVL4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
cellular component	0.81
protein domain	0.73
transcription factor perturbation	0.68
cell line	0.64

Protein Classes

PANTHER Classes

Protein / Ligase / Long-chain Fatty Acid Transport Protein 4

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc27 Family Of Fatty Acid Transporters / Long-chain Fatty Acid Transport Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.28   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.28   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0