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Tbio
SLC27A3
Long-chain fatty acid transport protein 3

Protein Summary
Description
Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Does not exhibit fatty acid transport activity (By similarity). This gene belongs to a family of integral membrane proteins and encodes a protein that is involved in lipid metabolism. The increased expression of this gene in human neural stem cells derived from induced pluripotent stem cells suggests that it plays an important role in early brain development. Naturally occurring mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368661
  • ENSP00000357650
  • ENSG00000143554
  • ENST00000623839
  • ENSP00000485585
  • ENSG00000263163
  • ENST00000624995
  • ENSP00000485061

Symbol
  • ACSVL3
  • FATP3
  • FATP3
  • ACSVL3
  • VLCS-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.8
PubMedID
0.66
tissue
0.66
histone modification site profile
0.65
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.26   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.26   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
LIMD1
Tbio
Novelty:  0.04868333
p_int:  0.999987423
p_ni:  0.000012577
Data Source:  BioPlex
ASIC1
Tchem
Family:  IC
Novelty:  0.00705323
p_int:  0.98848839
p_ni:  0.01151161
Score:  0.169
Data Source:  BioPlex,STRINGDB
ADAM33
Tchem
Family:  Enzyme
Novelty:  0.00584097
p_int:  0.988361846
p_ni:  0.011638154
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.982156936
p_ni:  0.017843064
Score:  0.158
Data Source:  BioPlex,STRINGDB
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.982022322
p_ni:  0.017977678
Data Source:  BioPlex
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.981602952
p_ni:  0.018397048
Score:  0.155
Data Source:  BioPlex,STRINGDB
BAG3
Tbio
Novelty:  0.0042967
p_int:  0.978844294
p_ni:  0.021155706
Score:  0.647
Data Source:  BioPlex,STRINGDB
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.966614682
p_ni:  0.033385318
Data Source:  BioPlex
KIR3DL2
Tbio
Novelty:  0.00321353
p_int:  0.965708642
p_ni:  0.034291358
Data Source:  BioPlex
STUB1
Tbio
Family:  Enzyme
Novelty:  0.00055102
p_int:  0.954615365
p_ni:  0.045384635
Score:  0.185
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of very long-chain fatty acyl-CoAs
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Synthesis of very long-chain fatty acyl-CoAs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
3
3
86
mathematical ability
4
3
4
85.2
body height
1
2
2
72.1
diet measurement
3
2
3
71.8
cognitive function measurement
3
1
3
65.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
86
mathematical ability
4
85.2
body height
2
72.1
diet measurement
3
71.8
cognitive function measurement
3
65.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 27 member 3
VGNC:53218
457334
Macaque
solute carrier family 27 member 3
718424
Mouse
MGI:1347358
26568
Rat
RGD:1310605
295219
Dog
solute carrier family 27 member 3
VGNC:46331
100855793
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 27 member 3
Macaque
solute carrier family 27 member 3
Mouse
Rat
Dog
solute carrier family 27 member 3
Publication Statistics
PubMed Score 10.26
PubMed score by year
PubTator Score 8.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title