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Tbio
SLC26A6
Solute carrier family 26 member 6

Protein Summary
Description
Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Function in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383733
  • ENSP00000373239
  • ENSG00000225697
  • ENST00000395550
  • ENSP00000378920
  • ENST00000420764
  • ENSP00000404684
  • ENST00000455886
  • ENSP00000401066
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
histone modification site profile
0.92
protein domain
0.85
biological process
0.83
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.62   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.62   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.999788339
p_ni:  0.000211661
Data Source:  BioPlex
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.991049539
p_ni:  0.008938059
p_wrong:  0.000012402
Data Source:  BioPlex
ENPP6
Tbio
Family:  Enzyme
Novelty:  0.06933544
p_int:  0.989624172
p_ni:  0.010375828
Data Source:  BioPlex
IRGC
Tbio
Family:  Enzyme
Novelty:  0.10743948
p_int:  0.938579096
p_ni:  0.061407422
p_wrong:  0.000013482
Data Source:  BioPlex
VAC14
Tbio
Novelty:  0.02677738
p_int:  0.929031766
p_ni:  0.049300864
p_wrong:  0.02166737
Score:  0.157
Data Source:  BioPlex,STRINGDB
SCPEP1
Tbio
Family:  Enzyme
Novelty:  0.08603794
p_int:  0.900827338
p_ni:  0.099145776
p_wrong:  0.000026886
Data Source:  BioPlex
PPP6R2
Tbio
Family:  Enzyme
Novelty:  0.12886225
p_int:  0.88694458
p_ni:  0.113034464
p_wrong:  0.000020956
Data Source:  BioPlex
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.878424929
p_ni:  0.121556008
p_wrong:  0.000019063
Score:  0.205
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.878424929
p_ni:  0.121556008
p_wrong:  0.000019063
Score:  0.191
Data Source:  BioPlex,STRINGDB
P2RX2
Tchem
Family:  IC
Novelty:  0.00241146
p_int:  0.873184981
p_ni:  0.125787212
p_wrong:  0.001027807
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Multifunctional anion exchangers (R-HSA-427601)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Multifunctional anion exchangers
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Multifunctional anion exchangers
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (47)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
5
5
89.5
self reported educational attainment
4
6
5
5.9
85.1
macrophage inflammatory protein 1b measurement
1
2
2
82.4
mathematical ability
2
3
3
81.7
chronotype measurement
2
2
1
1
79.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
5
89.5
self reported educational attainment
5
5.9
85.1
macrophage inflammatory protein 1b measurement
2
82.4
mathematical ability
3
81.7
chronotype measurement
1
1
79.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 26 member 6
VGNC:8002
100613198
Macaque
solute carrier family 26 member 6
106996923
Mouse
MGI:2159728
171429
Rat
RGD:1310197
301010
Dog
solute carrier family 26 member 6 [Source:HGNC Symbol;Acc:HGNC:14472]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 26 member 6
Macaque
solute carrier family 26 member 6
Mouse
Rat
Dog
solute carrier family 26 member 6 [Source:HGNC Symbol;Acc:HGNC:14472]
Publication Statistics
PubMed Score 107.62
PubMed score by year
PubTator Score 43.59
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title