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Tbio
SLC25A47
Solute carrier family 25 member 47

Protein Summary
Description
Uncoupling protein which may catalyze the physiological 'proton leak' in liver. Overexpression induces the dissipation of mitochondrial membrane potential. This gene encodes a member of a large family of mitochondrial transporters. The nuclear-encoded carrier protein is embedded in the inner mitochondrial membrane. This member of the family is thought to be an uncoupling protein that uncouples mitochondrial respiration from ATP synthesis by dissipating the transmembrane proton gradient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361529
  • ENSP00000354886
  • ENSG00000140107

Symbol
  • C14orf68
  • HDMCP
  • HDMCP
  • C14orf68
  • HMFN1655
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
cellular component
0.68
cell line
0.52
chemical
0.42
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
SLC5A12
Tdark
Family:  Transporter
Novelty:  0.12119749
Score:  0.691
Data Source:  STRINGDB
SLC33A1
Tchem
Family:  Transporter
Novelty:  0.05905408
Score:  0.573
Data Source:  STRINGDB
SLC22A13
Tbio
Family:  Transporter
Novelty:  0.04702774
Score:  0.562
Data Source:  STRINGDB
SLC15A2
Tchem
Family:  Transporter
Novelty:  0.00573108
Score:  0.546
Data Source:  STRINGDB
SLC13A3
Tbio
Family:  Transporter
Novelty:  0.02627177
Score:  0.533
Data Source:  STRINGDB
SLC25A53
Tdark
Family:  Transporter
Novelty:  10.42262895
Score:  0.511
Data Source:  STRINGDB
WDR25
Tdark
Novelty:  0.53632123
Score:  0.51
Data Source:  STRINGDB
SLC38A2
Tbio
Family:  Transporter
Novelty:  0.00808235
Score:  0.478
Data Source:  STRINGDB
IQCF6
Tdark
Novelty:  6.09485606
Score:  0.448
Data Source:  STRINGDB
PRPF39
Tbio
Novelty:  0.35760414
Score:  0.445
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
90.9
age at menarche
2
2
2
74.1
testosterone measurement
3
3
3
74
apolipoprotein A 1 measurement
1
1
1
59.9
pulse pressure measurement
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
90.9
age at menarche
2
74.1
testosterone measurement
3
74
apolipoprotein A 1 measurement
1
59.9
pulse pressure measurement
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 47
VGNC:8209
743099
Macaque
solute carrier family 25 member 47
100428969
Mouse
MGI:2144766
104910
Rat
RGD:1303247
299316
Dog
solute carrier family 25 member 47
VGNC:46317
612516
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 47
Macaque
solute carrier family 25 member 47
Mouse
Rat
Dog
solute carrier family 25 member 47
Publication Statistics
PubMed Score 2.00
PubMed score by year
PubTator Score 2.50
PubTator score by year
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Related Publications
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PMID
Year
Title