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Tbio
SLC25A46
Solute carrier family 25 member 46

Protein Summary
Description
May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission. This gene encodes a mitochondrial solute carrier protein family member. It functions in promoting mitochondrial fission, and prevents the formation of hyperfilamentous mitochondria. Mutation of this gene results in neuropathy and optic atrophy. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355943
  • ENSP00000348211
  • ENSG00000164209
  • ENST00000447245
  • ENSP00000399717
  • ENST00000504098
  • ENSP00000425708

Symbol
  • TB1
  • HMSN6B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
histone modification site profile
0.9
disease perturbation
0.83
transcription factor perturbation
0.74
tissue sample
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.73   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.73   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
SLC22A6
Tclin
Family:  Transporter
Novelty:  0.00389149
p_int:  0.995095442
p_ni:  0.004904558
Score:  0.296
Data Source:  BioPlex,STRINGDB
SLC22A16
Tbio
Family:  Transporter
Novelty:  0.03379851
p_int:  0.989204341
p_ni:  0.01079565
p_wrong:  9e-9
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.989098573
p_ni:  0.010900299
p_wrong:  0.000001129
Data Source:  BioPlex
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
p_int:  0.987983251
p_ni:  0.012016736
p_wrong:  1.3e-8
Data Source:  BioPlex
MFAP4
Tbio
Novelty:  0.02023782
p_int:  0.98016859
p_ni:  0.019829067
p_wrong:  0.000002343
Data Source:  BioPlex
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.966079613
p_ni:  0.0234385
p_wrong:  0.010481887
Data Source:  BioPlex
SLC22A15
Tdark
Family:  Transporter
Novelty:  0.22792289
p_int:  0.952216125
p_ni:  0.04647166
p_wrong:  0.001312215
Data Source:  BioPlex
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
p_int:  0.949306297
p_ni:  0.0442942
p_wrong:  0.006399503
Data Source:  BioPlex
PDCD1
Tclin
Novelty:  0.000448
p_int:  0.938919241
p_ni:  0.061029362
p_wrong:  0.000051397
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.934939742
p_ni:  0.065045341
p_wrong:  0.000014917
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
5
5
0
1.1
95.5
allergic disease
5
4
2
1.1
91.1
2
1
0
1.2
43.9
childhood onset asthma
1
1
0
1.1
33.8
allergic sensitization measurement
2
2
0
1.2
31.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
0
1.1
95.5
allergic disease
2
1.1
91.1
0
1.2
43.9
childhood onset asthma
0
1.1
33.8
allergic sensitization measurement
0
1.2
31.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 46
VGNC:13587
461986
Macaque
solute carrier family 25 member 46
705968
Mouse
MGI:1914703
67453
Rat
RGD:1305072
291709
Dog
solute carrier family 25 member 46
VGNC:46316
488876
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 46
Macaque
solute carrier family 25 member 46
Mouse
Rat
Dog
solute carrier family 25 member 46
Publication Statistics
PubMed Score 49.73
PubMed score by year
PubTator Score 10.42
PubTator score by year
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Related Publications
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PMID
Year
Title