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Tdark
SLC25A44
Solute carrier family 25 member 44

Protein Summary
Description
SLC25A44 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359511
  • ENSP00000352497
  • ENSG00000160785

Symbol
  • KIAA0446
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
transcription factor perturbation
0.74
histone modification site profile
0.73
microRNA
0.71
transcription factor binding site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.48   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.48   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.99998199
p_ni:  2.93e-7
p_wrong:  0.000017717
Score:  0.525
Data Source:  BioPlex,STRINGDB
IMPDH2
Tclin
Family:  Enzyme
Novelty:  0.00815361
p_int:  0.998471197
p_ni:  0.001528803
Score:  0.847
Data Source:  BioPlex,STRINGDB
LASP1
Tbio
Novelty:  0.00960538
p_int:  0.861536952
p_ni:  0.138451071
p_wrong:  0.000011978
Score:  0.353
Data Source:  BioPlex,STRINGDB
SLC25A35
Tdark
Family:  Transporter
Novelty:  1.19834062
Score:  0.664
Data Source:  STRINGDB
MRPL47
Tbio
Novelty:  0.05648009
Score:  0.66
Data Source:  STRINGDB
PMF1
Tbio
Novelty:  0.05319446
Score:  0.63
Data Source:  STRINGDB
KCNK17
Tchem
Family:  IC
Novelty:  0.04038829
Score:  0.609
Data Source:  STRINGDB
TLCD1
Tdark
Novelty:  0.76223034
Score:  0.581
Data Source:  STRINGDB
FAM151B
Tdark
Novelty:  2.00049418
Score:  0.577
Data Source:  STRINGDB
BORCS8
Tdark
Novelty:  1.62939642
Score:  0.566
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
2
3
97.3
HbA1c measurement
4
4
4
97.1
mean corpuscular hemoglobin concentration
3
3
3
91.1
leukocyte count
4
2
4
80.4
appendicular lean mass
3
3
4
76.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
97.3
HbA1c measurement
4
97.1
mean corpuscular hemoglobin concentration
3
91.1
leukocyte count
4
80.4
appendicular lean mass
4
76.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 44
VGNC:11913
457387
Macaque
solute carrier family 25 member 44
106992266
Mouse
MGI:2444391
229517
Rat
RGD:1307244
365841
Dog
solute carrier family 25 member 44
VGNC:46315
490415
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 44
Macaque
solute carrier family 25 member 44
Mouse
Rat
Dog
solute carrier family 25 member 44
Publication Statistics
PubMed Score 4.48
PubMed score by year
PubTator Score 0.39
PubTator score by year
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Related Publications
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PMID
Year
Title