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Tbio
SLC25A42
Mitochondrial coenzyme A transporter SLC25A42

Protein Summary
Description
Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate. This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondria and play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein is a mitochondrial transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318596
  • ENSP00000326693
  • ENSG00000181035
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
kinase perturbation
0.88
histone modification site profile
0.79
disease perturbation
0.74
protein domain
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.97   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.97   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.998150434
p_ni:  0.000010192
p_wrong:  0.001839374
Data Source:  BioPlex
TMEM161A
Tdark
Novelty:  0.74152096
Score:  0.794
Data Source:  STRINGDB
TMEM94
Tdark
Novelty:  0.39746809
Score:  0.776
Data Source:  STRINGDB
CASKIN2
Tdark
Novelty:  0.43801968
Score:  0.762
Data Source:  STRINGDB
PGPEP1
Tbio
Family:  Enzyme
Novelty:  0.00933029
Score:  0.725
Data Source:  STRINGDB
SLC35E1
Tdark
Family:  Transporter
Novelty:  0.95475737
Score:  0.715
Data Source:  STRINGDB
MEDAG
Tdark
Novelty:  0.22512353
Score:  0.689
Data Source:  STRINGDB
CHERP
Tbio
Novelty:  0.06955626
Score:  0.685
Data Source:  STRINGDB
CIB3
Tbio
Novelty:  0.02793645
Score:  0.677
Data Source:  STRINGDB
NR2C2AP
Tbio
Novelty:  0.29027758
Score:  0.67
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
2
2
93.3
triglyceride measurement
1
2
2
91
total cholesterol measurement
1
1
1
86
apolipoprotein B measurement
1
1
1
82.7
bilirubin measurement
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
93.3
triglyceride measurement
2
91
total cholesterol measurement
1
86
apolipoprotein B measurement
1
82.7
bilirubin measurement
1
61.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 42
VGNC:7784
736307
Macaque
solute carrier family 25 member 42
720321
Mouse
MGI:1920345
73095
Rat
RGD:1592346
689414
Dog
solute carrier family 25 member 42
VGNC:46313
609751
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 42
Macaque
solute carrier family 25 member 42
Mouse
Rat
Dog
solute carrier family 25 member 42
Publication Statistics
PubMed Score 7.97
PubMed score by year
PubTator Score 3.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title