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Tdark
SLC25A35
Solute carrier family 25 member 35

Protein Summary
Description
SLC25A35 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380067
  • ENSP00000369407
  • ENSG00000125434
  • ENST00000577745
  • ENSP00000464231
  • ENST00000579192
  • ENSP00000462395
  • ENST00000579681
  • ENSP00000464307
  • ENST00000580340
  • ENSP00000464071
  • ENST00000585311
  • ENSP00000464191
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.66
tissue sample
0.65
cell type or tissue
0.64
virus perturbation
0.64
cellular component
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.71   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.71   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
p_int:  0.999924289
p_ni:  0.000075658
p_wrong:  5.3e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999511616
p_ni:  0.000051466
p_wrong:  0.000436917
Data Source:  BioPlex
PMVK
Tchem
Family:  Enzyme
Novelty:  0.00468598
p_int:  0.993486663
p_ni:  0.006502548
p_wrong:  0.000010789
Score:  0.252
Data Source:  BioPlex,STRINGDB
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.90356296
p_ni:  0.001658173
p_wrong:  0.094778867
Data Source:  BioPlex
DDAH2
Tbio
Family:  Enzyme
Novelty:  0.00355931
p_int:  0.772967785
p_ni:  0.178477632
p_wrong:  0.048554583
Score:  0.199
Data Source:  BioPlex,STRINGDB
TAPT1
Tbio
Novelty:  0.12057711
Score:  0.792
Data Source:  STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
Score:  0.763
Data Source:  STRINGDB
SLC25A45
Tdark
Family:  Transporter
Novelty:  0.61869123
Score:  0.693
Data Source:  STRINGDB
SLC35D2
Tbio
Family:  Transporter
Novelty:  0.1135727
Score:  0.692
Data Source:  STRINGDB
SLC25A44
Tdark
Family:  Transporter
Novelty:  0.36924538
Score:  0.664
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
3
4
94.2
hemoglobin measurement
2
2
2
84.7
total cholesterol measurement
2
2
2
77.4
mean corpuscular volume
1
1
1
72.9
reticulocyte measurement
1
2
2
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
4
94.2
hemoglobin measurement
2
84.7
total cholesterol measurement
2
77.4
mean corpuscular volume
1
72.9
reticulocyte measurement
2
69.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 35
VGNC:51735
746472
Mouse
MGI:1919248
71998
Rat
RGD:1598229
497933
Dog
solute carrier family 25 member 35
VGNC:46309
489491
Horse
solute carrier family 25 member 35
VGNC:23108
100062525
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 35
Mouse
Rat
Dog
solute carrier family 25 member 35
Horse
solute carrier family 25 member 35
Publication Statistics
PubMed Score 0.71
PubMed score by year
PubTator Score 0.41
PubTator score by year
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Related Publications
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PMID
Year
Title