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Tbio
SLC25A33
Solute carrier family 25 member 33

Protein Summary
Description
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed:25320081). Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). Also transports guanine but not adenine (deoxy)nucleotides (PubMed:25320081). Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:20453889, PubMed:17596519). Participates in de ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302692
  • ENSP00000306328
  • ENSG00000171612

Symbol
  • PNC1
  • BMSC-MCP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
biological process
0.89
interacting protein
0.85
histone modification site profile
0.82
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.11   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.11   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.773567556
p_ni:  0.226432444
Score:  0.187
Data Source:  BioPlex,STRINGDB
SPSB1
Tbio
Novelty:  0.13839743
Score:  0.699
Data Source:  STRINGDB
NMNAT1
Tbio
Family:  Enzyme
Novelty:  0.01110899
Score:  0.687
Data Source:  STRINGDB
NOC2L
Tbio
Novelty:  0.00226536
Score:  0.684
Data Source:  STRINGDB
METTL17
Tbio
Family:  Enzyme
Novelty:  0.55944382
Score:  0.673
Data Source:  STRINGDB
DDX55
Tdark
Family:  Enzyme
Novelty:  0.27887497
Score:  0.665
Data Source:  STRINGDB
SLC6A6
Tbio
Family:  Transporter
Novelty:  0.00333868
Score:  0.647
Data Source:  STRINGDB
DDX52
Tbio
Family:  Enzyme
Novelty:  0.04618463
Score:  0.645
Data Source:  STRINGDB
SLC19A3
Tbio
Family:  Transporter
Novelty:  0.01200695
Score:  0.639
Data Source:  STRINGDB
MFSD2A
Tbio
Novelty:  0.01709114
Score:  0.638
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
83
eosinophil percentage of leukocytes
1
1
1
71.6
1
1
0
1.1
56.6
monocyte count
2
1
2
45.1
BMI-adjusted hip circumference
1
1
1
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
83
eosinophil percentage of leukocytes
1
71.6
0
1.1
56.6
monocyte count
2
45.1
BMI-adjusted hip circumference
1
7.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 33
VGNC:8105
457919
Mouse
MGI:1917806
70556
Rat
RGD:1583942
691431
Dog
solute carrier family 25 member 33
VGNC:46307
479599
Horse
solute carrier family 25 member 33
VGNC:23106
100057608
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 33
Mouse
Rat
Dog
solute carrier family 25 member 33
Horse
solute carrier family 25 member 33
Publication Statistics
PubMed Score 6.11
PubMed score by year
PubTator Score 13.91
PubTator score by year
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Related Publications
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PMID
Year
Title