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Tbio
SLC25A32
Mitochondrial folate transporter/carrier

Protein Summary
Description
Transports folate across the inner membranes of mitochondria. This gene encodes a member of the P(I/L)W subfamily of mitochondrial carrier family transport proteins. The encoded protein transports folate across the inner mitochondrial membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297578
  • ENSP00000297578
  • ENSG00000164933

Symbol
  • MFT
  • MFTC
  • MFT
  • MFTC
  • RREI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
histone modification site profile
0.85
kinase perturbation
0.81
virus perturbation
0.79
microRNA
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.05   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.05   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
CCDC25
Tbio
Novelty:  0.22601722
p_int:  0.999163343
p_ni:  0.0000159
p_wrong:  0.000820758
Score:  0.319
Data Source:  BioPlex,STRINGDB
PLPBP
Tbio
Family:  Enzyme
Novelty:  0.04352366
p_int:  0.98130283
p_ni:  0.016356483
p_wrong:  0.002340687
Score:  0.188
Data Source:  BioPlex,STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
p_int:  0.973248102
p_ni:  0.026751892
p_wrong:  7e-9
Score:  0.379
Data Source:  BioPlex,STRINGDB
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.971298097
p_ni:  0.028701903
Data Source:  BioPlex
TCEA1
Tbio
Novelty:  0.00547888
p_int:  0.945199426
p_ni:  0.054276233
p_wrong:  0.000524341
Score:  0.209
Data Source:  BioPlex,STRINGDB
SPAG7
Tbio
Novelty:  0.05905408
p_int:  0.9333665
p_ni:  0.066402038
p_wrong:  0.000231462
Score:  0.319
Data Source:  BioPlex,STRINGDB
PNPO
Tchem
Family:  Enzyme
Novelty:  0.00919993
p_int:  0.930177477
p_ni:  0.069818556
p_wrong:  0.000003966
Score:  0.267
Data Source:  BioPlex,STRINGDB
PMVK
Tchem
Family:  Enzyme
Novelty:  0.00468598
p_int:  0.885402695
p_ni:  0.007556899
p_wrong:  0.107040407
Score:  0.186
Data Source:  BioPlex,STRINGDB
CBFB
Tchem
Family:  TF
Novelty:  0.04825679
p_int:  0.871094916
p_ni:  0.018458557
p_wrong:  0.110446527
Score:  0.207
Data Source:  BioPlex,STRINGDB
IRGQ
Tdark
Family:  Enzyme
Novelty:  0.9065415
p_int:  0.85136088
p_ni:  0.148638876
p_wrong:  2.44e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 32
VGNC:7737
742856
Macaque
solute carrier family 25 member 32
694759
Mouse
MGI:1917156
69906
Rat
RGD:1565789
315023
Dog
solute carrier family 25 member 32
VGNC:46306
475064
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 32
Macaque
solute carrier family 25 member 32
Mouse
Rat
Dog
solute carrier family 25 member 32
Publication Statistics
PubMed Score 19.05
PubMed score by year
PubTator Score 32.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title