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Tbio
SLC25A3
Phosphate carrier protein, mitochondrial

Protein Summary
Description
Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP). The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000188376
  • ENSP00000188376
  • ENSG00000075415
  • ENST00000228318
  • ENSP00000228318
  • ENST00000401722
  • ENSP00000383898
  • ENST00000549338
  • ENSP00000447740
  • ENST00000551917
  • ENSP00000447310
  • ENST00000552981
  • ENSP00000448708

Symbol
  • PHC
  • PHC
  • PTP
  • OK/SW-cl.48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
kinase perturbation
1
virus perturbation
0.98
hub protein
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.3   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.3   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0