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Tbio
SLC25A26
S-adenosylmethionine mitochondrial carrier protein

Protein Summary
Description
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria. This gene is a member of the mitochondrial carrier family which includes nuclear-encoded transporters localized on the inner mitochondrial membranes. Members of the family transport important small molecules across the mitochondrial inner membrane. This protein is involved in the transport of S-adenosylmethionine (SAM) into the mitochondria. Mutations in this gene are associated with combined oxidative phosphorylation deficiency 28. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336733
  • ENSP00000336801
  • ENSG00000144741
  • ENST00000354883
  • ENSP00000346955
  • ENST00000632575
  • ENSP00000488865
  • ENSG00000282739
  • ENST00000633701
  • ENSP00000488659

Symbol
  • SAMC
  • SAMC
  • COXPD28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
tissue sample
0.63
transcription factor perturbation
0.61
transcription factor
0.59
cellular component
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.07   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.07   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
SPACA1
Tbio
Novelty:  0.07415851
p_int:  0.769372979
p_ni:  0.230347177
p_wrong:  0.000279844
Score:  0.224
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
THOC7
Tbio
Novelty:  0.16971494
Score:  0.745
Data Source:  STRINGDB
PPHLN1
Tbio
Novelty:  0.21311177
Score:  0.713
Data Source:  STRINGDB
PSMD6
Tbio
Family:  Enzyme
Novelty:  0.04419339
Score:  0.69
Data Source:  STRINGDB
PRICKLE2
Tbio
Novelty:  0.04809589
Score:  0.594
Data Source:  STRINGDB
ATXN7
Tbio
Novelty:  0.00323014
Score:  0.564
Data Source:  STRINGDB
ADAMTS9
Tbio
Family:  Enzyme
Novelty:  0.01447959
Score:  0.552
Data Source:  STRINGDB
LRIG1
Tbio
Novelty:  0.01078663
Score:  0.526
Data Source:  STRINGDB
SLC16A14
Tbio
Family:  Transporter
Novelty:  0.0669267
Score:  0.524
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (40)
Items per page:
1 – 5 of 40
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.1
80.8
2
3
0
1.1
80.8
cortical surface area measurement
1
2
0
9.6
74.1
cortical surface area measurement
1
2
0
9.6
74.1
red blood cell distribution width
2
2
2
73.7
Items per page:
1 – 5 of 40
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
80.8
0
1.1
80.8
cortical surface area measurement
0
9.6
74.1
cortical surface area measurement
0
9.6
74.1
red blood cell distribution width
2
73.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 25 member 26
697960
Mouse
MGI:1914832
67582
Dog
solute carrier family 25 member 26
VGNC:46302
611050
Cow
solute carrier family 25 member 26
VGNC:34752
614713
Opossum
solute carrier family 25 member 26
100019000
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 25 member 26
Mouse
Dog
solute carrier family 25 member 26
Cow
solute carrier family 25 member 26
Opossum
solute carrier family 25 member 26
Publication Statistics
PubMed Score 23.07
PubMed score by year
PubTator Score 27.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title