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Tbio
SLC25A24
Calcium-binding mitochondrial carrier protein SCaMC-1

Protein Summary
Description
Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix. This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370041
  • ENSP00000359058
  • ENSG00000085491
  • ENST00000565488
  • ENSP00000457733
  • ENST00000639032
  • ENSP00000492810
  • ENSG00000284468
  • ENST00000640416
  • ENSP00000491572

Symbol
  • APC1
  • MCSC1
  • SCAMC1
  • APC1
  • SCAMC1
  • SCAMC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
protein domain
0.92
molecular function
0.81
interacting protein
0.75
PubMedID
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.35   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.35   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.999617251
p_ni:  0.00038273
p_wrong:  1.9e-8
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.999409021
p_ni:  0.000590972
p_wrong:  6e-9
Data Source:  BioPlex
TMEM108
Tbio
Novelty:  0.08687599
p_int:  0.998973255
p_ni:  0.001026744
Data Source:  BioPlex
TMEM171
Tdark
Novelty:  2.00247773
p_int:  0.998745381
p_ni:  0.001254619
Data Source:  BioPlex
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.998477764
p_ni:  0.001522236
Score:  0.175
Data Source:  BioPlex,STRINGDB
SLC1A5
Tchem
Family:  Transporter
Novelty:  0.00201741
p_int:  0.99829112
p_ni:  0.001708846
p_wrong:  3.4e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.994442235
p_ni:  0.005553542
p_wrong:  0.000004223
Data Source:  BioPlex
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.990834425
p_ni:  0.009165383
p_wrong:  1.92e-7
Data Source:  BioPlex
MFSD4A
Tdark
Novelty:  0.62186415
p_int:  0.986325942
p_ni:  0.013673765
p_wrong:  2.93e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.98512956
p_ni:  0.014835914
p_wrong:  0.000034526
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
2
3
88
myeloid white cell count
2
2
2
82.8
leukocyte count
2
2
2
75
monocyte percentage of leukocytes
2
2
2
73.1
sum of neutrophil and eosinophil counts
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
88
myeloid white cell count
2
82.8
leukocyte count
2
75
monocyte percentage of leukocytes
2
73.1
sum of neutrophil and eosinophil counts
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 24
VGNC:8107
457937
Macaque
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
694803
Mouse
MGI:1917160
229731
Rat
RGD:1311982
310791
Dog
solute carrier family 25 member 24
VGNC:54068
611922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 24
Macaque
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
Mouse
Rat
Dog
solute carrier family 25 member 24
Publication Statistics
PubMed Score 18.35
PubMed score by year
PubTator Score 54.65
PubTator score by year
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Related Publications
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PMID
Year
Title