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Tbio
SLC25A23
Calcium-binding mitochondrial carrier protein SCaMC-3

Protein Summary
Description
Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane (PubMed:15123600). May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (PubMed:15123600). Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1 (PubMed:24430870).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264088
  • ENSP00000264088
  • ENSG00000125648
  • ENST00000301454
  • ENSP00000301454
  • ENST00000334510
  • ENSP00000334537

Symbol
  • APC2
  • MCSC2
  • SCAMC3
  • APC2
  • MCSC2
  • SCaMC-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
protein domain
0.85
transcription factor perturbation
0.84
small molecule perturbation
0.8
kinase perturbation
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.81   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.81   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
SLC25A25
Tbio
Family:  Transporter
Novelty:  0.05562006
p_int:  0.999999987
p_ni:  1.2e-8
p_wrong:  1e-9
Score:  0.83
Data Source:  BioPlex,STRINGDB
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.999063132
p_ni:  0.000936843
p_wrong:  2.5e-8
Data Source:  BioPlex
SYP
Tbio
Novelty:  0.00021543
p_int:  0.999055555
p_ni:  0.000944312
p_wrong:  1.33e-7
Score:  0.156
Data Source:  BioPlex,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.998465768
p_ni:  0.001512821
p_wrong:  0.000021411
Data Source:  BioPlex
PDCD1
Tclin
Novelty:  0.000448
p_int:  0.998225092
p_ni:  0.001773106
p_wrong:  0.000001802
Data Source:  BioPlex
SLC22A6
Tclin
Family:  Transporter
Novelty:  0.00389149
p_int:  0.998156697
p_ni:  0.001841909
p_wrong:  0.000001394
Score:  0.172
Data Source:  BioPlex,STRINGDB
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
p_int:  0.997800051
p_ni:  0.002192653
p_wrong:  0.000007296
Score:  0.288
Data Source:  BioPlex,STRINGDB
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.997484067
p_ni:  0.002512677
p_wrong:  0.000003256
Data Source:  BioPlex
AIFM1
Tbio
Novelty:  0.00940088
p_int:  0.997173147
p_ni:  0.002800276
p_wrong:  0.000026578
Score:  0.177
Data Source:  BioPlex,STRINGDB
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.99469994
p_ni:  0.005294741
p_wrong:  0.000005318
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
1
1
0
5.8
2.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
0
5.8
2.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 23
468684
Macaque
solute carrier family 25 member 23
699961
Mouse
MGI:1914222
66972
Rat
RGD:1588586
301113
Dog
solute carrier family 25 member 23
100855874
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 23
Macaque
solute carrier family 25 member 23
Mouse
Rat
Dog
solute carrier family 25 member 23
Publication Statistics
PubMed Score 9.81
PubMed score by year
PubTator Score 4.26
PubTator score by year
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Related Publications
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PMID
Year
Title