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Tbio
SLC25A11
Mitochondrial 2-oxoglutarate/malate carrier protein

Protein Summary
Description
Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity). The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225665
  • ENSP00000225665
  • ENSG00000108528
  • ENST00000544061
  • ENSP00000440804

Symbol
  • SLC20A4
  • OGC
  • SLC20A4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
transcription factor perturbation
0.94
co-expressed gene
0.85
disease perturbation
0.83
molecular function
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.43   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.43   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999929244
p_ni:  0.000070755
p_wrong:  1e-9
Score:  0.165
Data Source:  BioPlex,STRINGDB
PPP1R1A
Tbio
Family:  Enzyme
Novelty:  0.01565981
p_int:  0.999895614
p_ni:  0.00008765
p_wrong:  0.000016736
Score:  0.189
Data Source:  BioPlex,STRINGDB
SMAP2
Tbio
Novelty:  0.70006863
p_int:  0.999523181
p_ni:  0.000476818
Score:  0.225
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.988787637
p_ni:  0.011212363
Score:  0.225
Data Source:  BioPlex,STRINGDB
YTHDF1
Tbio
Novelty:  0.02063275
p_int:  0.981714277
p_ni:  0.018285723
Data Source:  BioPlex
PRG2
Tbio
Novelty:  0.00548995
p_int:  0.96071269
p_ni:  0.03928731
Data Source:  BioPlex
WDR45
Tbio
Novelty:  0.0148072
p_int:  0.955567654
p_ni:  0.044431627
p_wrong:  7.19e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.950441174
p_ni:  0.049558826
Score:  0.174
Data Source:  BioPlex,STRINGDB
YES1
Tclin
Family:  Kinase
Novelty:  0.00534936
p_int:  0.839784611
p_ni:  0.160215389
Data Source:  BioPlex
ZNF703
Tbio
Novelty:  0.03956045
p_int:  0.816151089
p_ni:  0.183723193
p_wrong:  0.000125718
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
7
8
4.2
98.7
mean platelet volume
3
5
7
96.6
platelet crit
2
3
3
92.4
blood metabolite measurement
2
2
2
89
sphingomyelin measurement
1
2
3
84.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
8
4.2
98.7
mean platelet volume
7
96.6
platelet crit
3
92.4
blood metabolite measurement
2
89
sphingomyelin measurement
3
84.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 11
VGNC:9619
468167
Macaque
solute carrier family 25 member 11
710569
Mouse
MGI:1915113
67863
Rat
RGD:708476
64201
Dog
solute carrier family 25 member 11
VGNC:46291
479470
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 11
Macaque
solute carrier family 25 member 11
Mouse
Rat
Dog
solute carrier family 25 member 11
Publication Statistics
PubMed Score 18.43
PubMed score by year
PubTator Score 23.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title