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Tbio
SLC25A10
Mitochondrial dicarboxylate carrier

Protein Summary
Description
Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane. This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331531
  • ENSP00000328403
  • ENSG00000183048
  • ENST00000350690
  • ENSP00000345580

Symbol
  • DIC
  • DIC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
transcription factor binding site profile
0.78
histone modification site profile
0.72
tissue sample
0.7
PubMedID
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.07   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.07   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.996907525
p_ni:  0.003092475
Data Source:  BioPlex
LACRT
Tbio
Novelty:  0.03333799
p_int:  0.995537852
p_ni:  0.004462144
p_wrong:  4e-9
Data Source:  BioPlex
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.961224641
p_ni:  0.038775359
Data Source:  BioPlex
CST4
Tbio
Novelty:  0.00773554
p_int:  0.880928638
p_ni:  0.119071356
p_wrong:  6e-9
Data Source:  BioPlex
PRR4
Tbio
Novelty:  0.01240966
p_int:  0.866704352
p_ni:  0.002982598
p_wrong:  0.13031305
Data Source:  BioPlex
MRPL17
Tdark
Novelty:  1.20541719
Score:  0.97
Data Source:  STRINGDB
MRPL36
Tbio
Novelty:  0.02929107
Score:  0.953
Data Source:  STRINGDB
MRPL9
Tdark
Novelty:  0.43920695
Score:  0.945
Data Source:  STRINGDB
RPL11
Tbio
Novelty:  0.00448962
Score:  0.939
Data Source:  STRINGDB
MRPL27
Tbio
Novelty:  0.15636105
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Degradation of cysteine and homocysteine (R-HSA-1614558)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of cysteine and homocysteine
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Degradation of cysteine and homocysteine
Gluconeogenesis
Glucose metabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
3
3
0
1.1
98
Myopia
3
3
0
1.2
92.7
ganglion cell inner plexiform layer thickness measurement
1
1
1
87.4
optic disc size measurement
1
1
1
82.8
eye color
1
1
1
81.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
98
Myopia
0
1.2
92.7
ganglion cell inner plexiform layer thickness measurement
1
87.4
optic disc size measurement
1
82.8
eye color
1
81.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 25 member 10
714494
Mouse
MGI:1353497
27376
Rat
RGD:621430
170943
Opossum
mitochondrial dicarboxylate carrier-like
100030196
Xenopus
solute carrier family 25 member 10
XB-GENE-955175
549772
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 25 member 10
Mouse
Rat
Opossum
mitochondrial dicarboxylate carrier-like
Xenopus
solute carrier family 25 member 10
Publication Statistics
PubMed Score 18.07
PubMed score by year
PubTator Score 27.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title